This is my.cnf configuration for onw of our running 128 GB server, If any one want to follow this cofiguration or point out the issues is appreciated
#MariadB [mysqld] datadir=/var/lib/mysql socket=/var/lib/mysql/mysql.sock symbolic-links=0 log-error=/var/log/mysqld.log pid-file=/var/run/mysqld/mysqld.pid local-infile=0 innodb=on max_connections = 5000 max_user_connections=1000 key_buffer_size = 512M myisam_sort_buffer_size = 128M read_buffer_size = 1M table_open_cache = 5000 thread_cache_size = 100 wait_timeout = 30 connect_timeout = 30 tmp_table_size = 2G max_heap_table_size = 2G max_allowed_packet = 32M net_buffer_length = 2M max_connect_errors = 100 concurrent_insert = 2 read_rnd_buffer_size = 2M bulk_insert_buffer_size = 2G query_cache_limit = 1M query_cache_size = 128M query_cache_type = 1 query_prealloc_size = 128M query_alloc_block_size = 128M transaction_alloc_block_size = 128M transaction_prealloc_size = 128M max_write_lock_count = 16 slow_query_log log-error external-locking=FALSE open_files_limit=50000 character-set-server = utf8 collation-server = utf8_general_ci
[client] socket = /var/lib/mysql/mysql.sock default-character-set = utf8
[mysqld_safe] nice = -15
[mysqldump] quick quote-names max_allowed_packet = 128M
[isamchk] key_buffer = 384M sort_buffer = 384M read_buffer = 256M write_buffer = 256M
[myisamchk] key_buffer = 384M sort_buffer = 384M read_buffer = 256M write_buffer = 256M
table_cache = 512 table_open_cache = 512 tmpdir = /tmp
thread_concurrency = 16 thread_cache_size = 100
max_heap_table_size = 2G bulk_insert_buffer_size = 2G tmp_table_size = 2G
key_buffer = 1M myisam_sort_buffer_size = 128M myisam_max_sort_file_size = 256M myisam_repair_threads = 4 myisam_recover = BACKUP
sort_buffer_size = 2M join_buffer_size = 2M thread_stack = 512K read_buffer_size = 2M read_rnd_buffer_size = 2M binlog_cache_size = 128K
XA transactions = 1 sync_binlog = 1
innodb_data_home_dir = /var/lib/mysql innodb_data_file_path = ibdata1:128M;ibdata2:10M:autoextend innodb_log_file_size = 768M innodb_log_files_in_group = 4 innodb_buffer_pool_size = 72G innodb_additional_mem_pool_size = 4M #innodb_status_file #innodb_file_per_table innodb_flush_log_at_trx_commit = 2 innodb_table_locks = 0 innodb_log_buffer_size = 256M innodb_lock_wait_timeout = 60 innodb_thread_concurrency = 16 innodb_commit_concurrency = 16 innodb_flush_method = O_DIRECT #O_DIRECT = local/DAS #O_DSYNC = SAN/iSCSI innodb_support_xa = 0 #skip-innodb-doublewrite
!includedir /etc/my.cnf.d