diff --git a/tools/dockerfile/interoptest/grpc_interop_node/build_interop.sh b/tools/dockerfile/interoptest/grpc_interop_node/build_interop.sh
index 93aab402aa21c..c16efc1d35481 100755
--- a/tools/dockerfile/interoptest/grpc_interop_node/build_interop.sh
+++ b/tools/dockerfile/interoptest/grpc_interop_node/build_interop.sh
@@ -17,17 +17,18 @@
 set -e
 
 mkdir -p /var/local/git
-git clone /var/local/jenkins/grpc /var/local/git/grpc
+git clone /var/local/jenkins/grpc-node /var/local/git/grpc-node
 # clone gRPC submodules, use data from locally cloned submodules where possible
-(cd /var/local/jenkins/grpc/ && git submodule foreach 'cd /var/local/git/grpc \
-&& git submodule update --init --reference /var/local/jenkins/grpc/${name} \
+(cd /var/local/jenkins/grpc-node/ && git submodule foreach 'cd /var/local/git/grpc-node \
+&& git submodule update --init --recursive --reference /var/local/jenkins/grpc-node/${name} \
 ${name}')
 
 # copy service account keys if available
 cp -r /var/local/jenkins/service_account $HOME || true
 
-cd /var/local/git/grpc
+cd /var/local/git/grpc-node
 
 # build Node interop client & server
-npm install -g node-gyp
-npm install --unsafe-perm --build-from-source
+npm install -g node-gyp gulp
+npm install
+gulp setup
diff --git a/tools/internal_ci/helper_scripts/prepare_build_interop_rc b/tools/internal_ci/helper_scripts/prepare_build_interop_rc
index 859ce621f97b9..db978c8b3ff17 100644
--- a/tools/internal_ci/helper_scripts/prepare_build_interop_rc
+++ b/tools/internal_ci/helper_scripts/prepare_build_interop_rc
@@ -26,6 +26,7 @@ git submodule update --init
 # Set up gRPC-Go and gRPC-Java to test
 git clone --recursive https://github.com/grpc/grpc-go ./../grpc-go
 git clone --recursive https://github.com/grpc/grpc-java ./../grpc-java
+git clone --recursive https://github.com/grpc/grpc-node ./../grpc-node
 
 # Download json file.
 mkdir ~/service_account
diff --git a/tools/internal_ci/helper_scripts/prepare_build_macos_interop_rc b/tools/internal_ci/helper_scripts/prepare_build_macos_interop_rc
index f467ac006af39..bb046defb17c8 100644
--- a/tools/internal_ci/helper_scripts/prepare_build_macos_interop_rc
+++ b/tools/internal_ci/helper_scripts/prepare_build_macos_interop_rc
@@ -30,6 +30,7 @@ brew install md5sha1sum
 # Set up gRPC-Go and gRPC-Java to test
 git clone --recursive https://github.com/grpc/grpc-go ./../grpc-go
 git clone --recursive https://github.com/grpc/grpc-java ./../grpc-java
+git clone --recursive https://github.com/grpc/grpc-node ./../grpc-node
 
 # Set up Docker for Mac
 docker-machine create -d virtualbox --virtualbox-share-folder "/Users/kbuilder/workspace:" default
diff --git a/tools/interop_matrix/create_matrix_images.py b/tools/interop_matrix/create_matrix_images.py
index 119cbd2e8806f..67355e7fbf9aa 100755
--- a/tools/interop_matrix/create_matrix_images.py
+++ b/tools/interop_matrix/create_matrix_images.py
@@ -174,7 +174,7 @@ def build_all_images_for_release(lang, release):
   # If we not using current tree or the sibling for grpc stack, do checkout.
   if args.git_checkout:
     stack_base = checkout_grpc_stack(lang, release)
-    var ={'go': 'GRPC_GO_ROOT', 'java': 'GRPC_JAVA_ROOT'}.get(lang, 'GRPC_ROOT')
+    var ={'go': 'GRPC_GO_ROOT', 'java': 'GRPC_JAVA_ROOT', 'node': 'GRPC_NODE_ROOT'}.get(lang, 'GRPC_ROOT')
     env[var] = stack_base
 
   for runtime in client_matrix.LANG_RUNTIME_MATRIX[lang]:
diff --git a/tools/run_tests/dockerize/build_interop_image.sh b/tools/run_tests/dockerize/build_interop_image.sh
index 9d8ad5325c1a8..09e062980d87b 100755
--- a/tools/run_tests/dockerize/build_interop_image.sh
+++ b/tools/run_tests/dockerize/build_interop_image.sh
@@ -48,6 +48,14 @@ else
   echo "WARNING: grpc-go not found, it won't be mounted to the docker container."
 fi
 
+echo "GRPC_NODE_ROOT: ${GRPC_NODE_ROOT:=$(cd ../grpc-node && pwd)}"
+if [ -n "$GRPC_NODE_ROOT" ]
+then
+  MOUNT_ARGS+=" -v $GRPC_NODE_ROOT:/var/local/jenkins/grpc-node:ro"
+else
+  echo "WARNING: grpc-node not found, it won't be mounted to the docker container."
+fi
+
 mkdir -p /tmp/ccache
 
 # Mount service account dir if available.
diff --git a/tools/run_tests/run_interop_tests.py b/tools/run_tests/run_interop_tests.py
index 2f826871a09b2..b20d6ce88e6f6 100755
--- a/tools/run_tests/run_interop_tests.py
+++ b/tools/run_tests/run_interop_tests.py
@@ -313,20 +313,20 @@ def __str__(self):
 class NodeLanguage:
 
   def __init__(self):
-    self.client_cwd = None
-    self.server_cwd = None
+    self.client_cwd = '../grpc-node'
+    self.server_cwd = '../grpc-node'
     self.safename = str(self)
 
   def client_cmd(self, args):
-    return ['tools/run_tests/interop/with_nvm.sh',
-            'node', 'src/node/interop/interop_client.js'] + args
+    return ['packages/grpc-native-core/deps/grpc/tools/run_tests/interop/with_nvm.sh',
+            'node', 'test/interop/interop_client.js'] + args
 
   def cloud_to_prod_env(self):
     return {}
 
   def server_cmd(self, args):
-    return ['tools/run_tests/interop/with_nvm.sh',
-            'node', 'src/node/interop/interop_server.js'] + args
+    return ['packages/grpc-native-core/deps/grpc/tools/run_tests/interop/with_nvm.sh',
+            'node', 'test/interop/interop_server.js'] + args
 
   def global_env(self):
     return {}