A package for performing Mendelian randomization using GWAS summary data. It uses the IEU GWAS database to obtain data automatically, and a wide range of methods to run the analysis. You can use the MR-Base web app to try out a limited range of the functionality in this package, but for any serious work we strongly recommend using this R package.

We have made substantial changes to the package, database and reference panels. For full details of the changes, please visit https://mrcieu.github.io/TwoSampleMR/articles/gwas2020.html

Users running Windows and macOS, to install the latest version of TwoSampleMR please install from our MRC IEU r-universe

install.packages("TwoSampleMR", repos = c("https://mrcieu.r-universe.dev", "https://cloud.r-project.org"))

Users running Linux or WebR please see the following instructions.

To update the package run the same command again.

install.packages("remotes")
remotes::install_github("MRCIEU/TwoSampleMR")

To update the package just run the remotes::install_github("MRCIEU/TwoSampleMR") command again.

A docker image containing R with the TwoSampleMR package pre-installed is available here: https://hub.docker.com/r/mrcieu/twosamplemr

Full documentation available here: https://mrcieu.github.io/TwoSampleMR/