Genome Biology

Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy

Authors: Anastasia E. Hains, Kashish Chetal, Tsunetoshi Nakatani, Joana G. Marques, Andreas Ettinger, Carlos A. O. Biagi Junior, Adriana Gonzalez-Sandoval, Renjitha Pillai, Mariella G. Filbin, Maria-Elena Torres-Padilla, Ruslan I. Sadreyev and Capucine Van Rechem

Content type: Research 20 December 2024
Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA

Authors: Tongyue Sun, Jinqi Yuan, Yacheng Zhu, Jingqi Li, Shen Yang, Junpeng Zhou, Xinzhou Ge, Susu Qu, Wei Li, Jingyi Jessica Li and Yumei Li

Content type: Research 19 December 2024
TEMPTED: time-informed dimensionality reduction for longitudinal microbiome studies

Authors: Pixu Shi, Cameron Martino, Rungang Han, Stefan Janssen, Gregory Buck, Myrna Serrano, Kouros Owzar, Rob Knight, Liat Shenhav and Anru R. Zhang

Content type: Method 19 December 2024
Transcriptional regulatory network reveals key transcription factors for regulating agronomic traits in soybean

Authors: Wu Jiao, Mangmang Wang, Yijian Guan, Wei Guo, Chang Zhang, Yuanchun Wei, Zhenwei Zhao, Hongyu Ma, Longfei Wang, Xinyu Jiang, Wenxue Ye, Dong Cao and Qingxin Song

Content type: Research 18 December 2024
EpiGePT: a pretrained transformer-based language model for context-specific human epigenomics

Authors: Zijing Gao, Qiao Liu, Wanwen Zeng, Rui Jiang and Wing Hung Wong

Content type: Method 18 December 2024

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Differential expression analysis for sequence count data

Authors: Simon Anders and Wolfgang Huber

Content type: Method 27 October 2010
A survey of best practices for RNA-seq data analysis

Authors: Ana Conesa, Pedro Madrigal, Sonia Tarazona, David Gomez-Cabrero, Alejandra Cervera, Andrew McPherson, Michał Wojciech Szcześniak, Daniel J. Gaffney, Laura L. Elo, Xuegong Zhang and Ali Mortazavi

Content type: Review 26 January 2016

The Erratum to this article has been published in Genome Biology 2016 17:181
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Authors: Michael I Love, Wolfgang Huber and Simon Anders

Content type: METHOD 5 December 2014
The Kardashian index: a measure of discrepant social media profile for scientists

Authors: Neil Hall

Content type: Comment 30 July 2014
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Authors: Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe and Frank Speleman

Content type: Research 18 June 2002

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The Editors and staff of Genome Biology would like to warmly thank the Reviewers whose comments helped to shape the journal, for their invaluable assistance with review of manuscripts in 2020.

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Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy

Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA

TEMPTED: time-informed dimensionality reduction for longitudinal microbiome studies

Transcriptional regulatory network reveals key transcription factors for regulating agronomic traits in soybean

EpiGePT: a pretrained transformer-based language model for context-specific human epigenomics

Differential expression analysis for sequence count data

A survey of best practices for RNA-seq data analysis

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

The Kardashian index: a measure of discrepant social media profile for scientists

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Latest articles from Genome Medicine

A tool for CRISPR-Cas9 sgRNA evaluation based on computational models of gene expression

Tracing carriage, acquisition, and transmission of ESBL-producing Escherichia coli over two years in a tertiary care hospital

HGVS Nomenclature 2024: improvements to community engagement, usability, and computability

Focus: Fertility

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