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Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection

  • HIV Pathogenesis and Treatment (AL Landay, Section Editor)
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Abstract

In the current era of combination antiretroviral therapy (ART), human immunodeficiency virus (HIV)-infected individuals are living longer and healthier lives. Nevertheless, HIV-infected persons are at greater risk for age-related disorders, which have been linked to residual immune dysfunction and inflammation. HIV-infected individuals are almost universally co-infected with cytomegalovirus (CMV) and both viruses are associated with inflammation-related morbidities. Therefore, a detailed investigation of the relationship between CMV and aging-related morbidities emerging during chronic HIV infection is warranted. Here, we review the literature on how CMV co-infection affects HIV infection and host immunity and we discuss the gaps in our knowledge that need elucidation.

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Acknowledgments

This work was supported by the Department of Veterans Affairs and grants from the National Institutes of Health: AI43638, AI100665, MH097520, DA034978, AI036214, AI007384, AI027763, AI106039, AI074621, AI110181, 7-UM1 AI068636-07, AI-36219, P30-AI027763, amfAR grant 108537 with support from FAIR, UL1TR000100, the James B. Pendleton Charitable Trust.

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  1. Case Western Reserve University/University Hospitals Case Medical Center, 2109 Adelbert Road, BRB 1048B, Cleveland, OH, 44106, USA

    Michael L. Freeman & Michael M. Lederman

  2. University of California, San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA

    Sara Gianella

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  1. Michael L. Freeman
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  2. Michael M. Lederman
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Correspondence to Sara Gianella.

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Michael L. Freeman, Michael M. Lederman, and Sara Gianella declare that they have no conflict of interest.

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This article is part of the Topical Collection on HIV Pathogenesis and Treatment

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Freeman, M.L., Lederman, M.M. & Gianella, S. Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection. Curr HIV/AIDS Rep 13, 10–19 (2016). https://doi.org/10.1007/s11904-016-0297-9

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