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Glomerular basement membrane composition and the filtration barrier

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Abstract

The glomerular basement membrane (GBM) is an especially thick basement membrane that contributes importantly to the kidney’s filtration barrier. The GBM derives from the fusion of separate podocyte and endothelial cell basement membranes during glomerulogenesis and consists primarily of laminin-521 (α5β2γ1), collagen α3α4α5(IV), nidogens-1 and -2, and agrin. Of these nine proteins, mutations in the genes encoding four of them (LAMB2, COL4A3, COL4A4, and COL4A5) cause glomerular disease in humans as well as in mice. Furthermore, mutation of a fifth (Lama5) gene in podocytes in mice causes proteinuria, nephrotic syndrome, and progression to renal failure. These results highlight the importance of the GBM for establishing and maintaining a properly functioning glomerular filtration barrier.

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Acknowledgments

My relevant research is supported by NIH grants R01DK078314, R01GM060432, and R01DK081156.

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  1. Renal Division, Department of Internal Medicine, School of Medicine, Washington University, 660 S. Euclid Ave., Box 8126, St. Louis, MO, 63110, USA

    Jeffrey H. Miner

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Correspondence to Jeffrey H. Miner.

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Miner, J.H. Glomerular basement membrane composition and the filtration barrier. Pediatr Nephrol 26, 1413–1417 (2011). https://doi.org/10.1007/s00467-011-1785-1

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