Save

Variations in diet cause alterations in microbiota and metabolites that follow changes in disease severity in a multiple sclerosis model

In: Beneficial Microbes
Authors:
J.E. Libbey Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA

Search for other papers by J.E. Libbey in
Current site
Google Scholar
PubMed
Close
,
J.M. Sanchez Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA

Search for other papers by J.M. Sanchez in
Current site
Google Scholar
PubMed
Close
,
D.J. Doty Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA

Search for other papers by D.J. Doty in
Current site
Google Scholar
PubMed
Close
,
J.T. Sim Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA

Search for other papers by J.T. Sim in
Current site
Google Scholar
PubMed
Close
,
M.F. Cusick Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA
Baylor College of Medicine, Division of Abdominal Transplantation, Neurosensory Center, Houston, TX 77030, USA

Search for other papers by M.F. Cusick in
Current site
Google Scholar
PubMed
Close
,
J.E. Cox Department of Biochemistry and Metabolomics Core, University of Utah, 15 North Medical Drive East, A306 EEJMRB, Salt Lake City, UT 84112, USA

Search for other papers by J.E. Cox in
Current site
Google Scholar
PubMed
Close
,
K.F. Fischer Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA
uBiota LLC, 825 N 300 W STE: NE-200, Salt Lake City, UT 84103, USA

Search for other papers by K.F. Fischer in
Current site
Google Scholar
PubMed
Close
,
J.L. Round Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA

Search for other papers by J.L. Round in
Current site
Google Scholar
PubMed
Close
, and
R.S. Fujinami Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA

Search for other papers by R.S. Fujinami in
Current site
Google Scholar
PubMed
Close
Download Citation Get Permissions

Access options

Get access to the full article by using one of the access options below.

Institutional Login

Log in with Open Athens, Shibboleth, or your institutional credentials

Login via Institution

Purchase

Buy instant access (PDF download and unlimited online access):

$40.00

Multiple sclerosis (MS) is a metabolically demanding disease involving immune-mediated destruction of myelin in the central nervous system. We previously demonstrated a significant alteration in disease course in the experimental autoimmune encephalomyelitis (EAE) preclinical model of MS due to diet. Based on the established crosstalk between metabolism and gut microbiota, we took an unbiased sampling of microbiota, in the stool, and metabolites, in the serum and stool, from mice (Mus musculus) on the two different diets, the Teklad global soy protein-free extruded rodent diet (irradiated diet) and the Teklad sterilisable rodent diet (autoclaved diet). Within the microbiota, the genus Lactobacillus was found to be inversely correlated with EAE severity. Therapeutic treatment with Lactobacillus paracasei resulted in a significant reduction in the incidence of disease, clinical scores and the amount of weight loss in EAE mice. Within the metabolites, we identified shifts in glycolysis and the tricarboxylic acid cycle that may explain the differences in disease severity between the different diets in EAE. This work begins to elucidate the relationship between diet, microbiota and metabolism in the EAE preclinical model of MS and identifies targets for further study with the goal to more specifically probe the complex metabolic interaction at play in EAE that may have translational relevance to MS patients.

Content Metrics

All Time Past Year Past 30 Days
Abstract Views 103 103 15
Full Text Views 15 4 2
PDF Views & Downloads 10 10 2