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Factors associated with survival in patients with meningioma

Bridget J. McCarthy Department of Biostatistics/Epidemiology, University of Illinois at Chicago, Chicago, Illinois; Department of Neuro-Oncology/Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Research, Chicago Institute of Neurosurgery and Neuroresearch, Chicago, Illinois; National Cancer Data Base, Commission on Cancer, American College of Surgeons, Chicago, Illinois; and Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia

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 Ph.D.
,
Faith G. Davis Department of Biostatistics/Epidemiology, University of Illinois at Chicago, Chicago, Illinois; Department of Neuro-Oncology/Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Research, Chicago Institute of Neurosurgery and Neuroresearch, Chicago, Illinois; National Cancer Data Base, Commission on Cancer, American College of Surgeons, Chicago, Illinois; and Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia

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Sally Freels Department of Biostatistics/Epidemiology, University of Illinois at Chicago, Chicago, Illinois; Department of Neuro-Oncology/Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Research, Chicago Institute of Neurosurgery and Neuroresearch, Chicago, Illinois; National Cancer Data Base, Commission on Cancer, American College of Surgeons, Chicago, Illinois; and Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia

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Tanya S. Surawicz Department of Biostatistics/Epidemiology, University of Illinois at Chicago, Chicago, Illinois; Department of Neuro-Oncology/Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Research, Chicago Institute of Neurosurgery and Neuroresearch, Chicago, Illinois; National Cancer Data Base, Commission on Cancer, American College of Surgeons, Chicago, Illinois; and Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia

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Denise M. Damek Department of Biostatistics/Epidemiology, University of Illinois at Chicago, Chicago, Illinois; Department of Neuro-Oncology/Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Research, Chicago Institute of Neurosurgery and Neuroresearch, Chicago, Illinois; National Cancer Data Base, Commission on Cancer, American College of Surgeons, Chicago, Illinois; and Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia

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James Grutsch Department of Biostatistics/Epidemiology, University of Illinois at Chicago, Chicago, Illinois; Department of Neuro-Oncology/Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Research, Chicago Institute of Neurosurgery and Neuroresearch, Chicago, Illinois; National Cancer Data Base, Commission on Cancer, American College of Surgeons, Chicago, Illinois; and Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia

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Herman R. Menck Department of Biostatistics/Epidemiology, University of Illinois at Chicago, Chicago, Illinois; Department of Neuro-Oncology/Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Research, Chicago Institute of Neurosurgery and Neuroresearch, Chicago, Illinois; National Cancer Data Base, Commission on Cancer, American College of Surgeons, Chicago, Illinois; and Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia

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Edward R. Laws Jr. Department of Biostatistics/Epidemiology, University of Illinois at Chicago, Chicago, Illinois; Department of Neuro-Oncology/Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Research, Chicago Institute of Neurosurgery and Neuroresearch, Chicago, Illinois; National Cancer Data Base, Commission on Cancer, American College of Surgeons, Chicago, Illinois; and Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia

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 M.D.
Page Range:
831–839
Volume/Issue:
Volume 88: Issue 5
DOI link:
https://doi.org/10.3171/jns.1998.88.5.0831
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Object. To explore factors affecting the survival rate in patients with meningiomas, the authors used the National Cancer Data Base (NCDB), which includes tumors from approximately 1000 hospitals participating in the American College of Surgeons tumor registry program.

Methods. Analysis included over 9000 cases diagnosed from 1985 to 1988 and 1990 to 1992. Survival estimates were computed and prognostic factors were identified using a proportional hazards model. The overall 5-year survival rate was 69% and it declined with patient age. This rate was 81% in patients aged 21 to 64 years and 56% for patients 65 years of age or older. When patients were grouped by the histological type of their tumors, those with benign tumors had an overall 5-year survival rate of 70%, whereas the overall 5-year survival rates in patients with atypical and malignant meningiomas were 75% and 55%, respectively. Prognostic factors for benign tumors included age at diagnosis, tumor size, whether treated surgically, hospital type, and radiation therapy; for malignant tumors, the prognostic factors included: age at diagnosis, whether treated surgically, and radiation therapy. These factors were statistically significant. The 5-year rate for recurrence of symptoms (regardless of the method of treatment) was 19.2% for those with benign tumors and 32.4% for those with malignant tumors. In patients whose benign tumor had been completely removed, the 5-year rate of tumor recurrence was 20.5%.

Conclusions. Although not population-based, the NCDB has the potential for providing pertinent information regarding patient characteristics and methods of treatment for benign, as well as malignant, brain tumors.

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Contributor Notes

Address reprint requests to: Bridget J. McCarthy, Ph.D., Department of Biostatistics/Epidemiology, University of Illinois at Chicago, 2121 West Taylor, M/C 922, Chicago, Illinois 60612.
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