This site uses cookies, tags, and tracking settings to store information that help give you the very best browsing experience. Dismiss this warning

Specific cytotoxic activity of T lymphocyte clones derived from a patient with gliosarcoma

Shin-Ichi Miyatake Department of Neurosurgery and Institute for Virus Research, Kyoto University, Kyoto, Japan

Search for other papers by Shin-Ichi Miyatake in
Current site
Google Scholar
PubMed Close
 M.D.
,
Haruhiko Kikuchi Department of Neurosurgery and Institute for Virus Research, Kyoto University, Kyoto, Japan

Search for other papers by Haruhiko Kikuchi in
Current site
Google Scholar
PubMed Close
 M.D.
,
Kohichi Iwasaki Department of Neurosurgery and Institute for Virus Research, Kyoto University, Kyoto, Japan

Search for other papers by Kohichi Iwasaki in
Current site
Google Scholar
PubMed Close
 M.D.
,
Junkoh Yamashita Department of Neurosurgery and Institute for Virus Research, Kyoto University, Kyoto, Japan

Search for other papers by Junkoh Yamashita in
Current site
Google Scholar
PubMed Close
 M.D.
,
Zu-You-Li Department of Neurosurgery and Institute for Virus Research, Kyoto University, Kyoto, Japan

Search for other papers by Zu-You-Li in
Current site
Google Scholar
PubMed Close
 M.D.
,
Yuzirou Namba Department of Neurosurgery and Institute for Virus Research, Kyoto University, Kyoto, Japan

Search for other papers by Yuzirou Namba in
Current site
Google Scholar
PubMed Close
 M.D.
, and
Masao Hanaoka Department of Neurosurgery and Institute for Virus Research, Kyoto University, Kyoto, Japan

Search for other papers by Masao Hanaoka in
Current site
Google Scholar
PubMed Close
 M.D.
Page Range:
751–759
Volume/Issue:
Volume 69: Issue 5
DOI link:
https://doi.org/10.3171/jns.1988.69.5.0751
Restricted access

Purchase Now

USD  $45.00

JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

USD  $536.00

JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

USD  $636.00
Click here for subscription options

  • Purchase Now

    USD  $45.00

  • JNS + Pediatrics - 1 year subscription bundle (Individuals Only)

    USD  $536.00

  • JNS + Pediatrics + Spine - 1 year subscription bundle (Individuals Only)

    USD  $636.00
USD  $45.00
USD  $536.00
USD  $636.00
Print or Print + Online Sign in

✓ Eleven lymphocyte clones were established from the peripheral blood lymphocytes of a patient with gliosarcoma by means of autologous tumor stimulation and the limiting-dilution technique with recombinant interleukin-2. Ten of the 11 clones were cytotoxic against the autologous tumor cell line GI-1. Seven of the 10 clones were also cytotoxic against allogeneic brain-tumor lines and HeLa cells, one clone was cytotoxic against several target cells, and two clones were specifically cytotoxic against GI-1 and allogeneic brain-tumor cells. One of the 11 clones was not cytotoxic against any target cells tested. Lymphokine-activated killer cells induced by recombinant interleukin-2 alone exhibited cytotoxic activity against all target tumor cells tested. Surface phenotypic analysis revealed that all lymphocyte clones expressed CD3 antigen, some expressed CD4 antigen, and others expressed CD8 antigen. These clones seemed to be antigen-specific cytotoxic T lymphocyte clones. Analysis with these antigen-specific cytotoxic T lymphocyte clones may be useful in the elucidation of tumor-specific or tumor-associated antigens on autologous tumor cells.

  • Collapse
  • Expand
Publish Before Print
Volume: 142 (2025)
Show Items
Volume: 141 (2024)
Show Items
Volume: 140 (2024)
Show Items
Volume: 139 (2023)
Show Items
Volume: 138 (2023)
Show Items
Volume: 137 (2022)
Show Items
Volume: 136 (2022)
Show Items
Volume: 135 (2021)
Show Items
Volume: 134 (2021)
Show Items
Volume: 133 (2020)
Show Items
Volume: 132 (2020)
Show Items
Volume: 131 (2019)
Show Items
Volume: 130 (2019)
Show Items
Volume: 129 (2018)
Show Items
Volume: 128 (2018)
Show Items
Volume: 127 (2017)
Show Items
Volume: 126 (2017)
Show Items
Volume: 125 (2016)
Show Items
Volume: 124 (2016)
Show Items
Volume: 123 (2015)
Show Items
Volume: 122 (2015)
Show Items
Volume: 121 (2014)
Show Items
Volume: 120 (2014)
Show Items
Volume: 119 (2013)
Show Items
Volume: 118 (2013)
Show Items
Volume: 117 (2012)
Show Items
Volume: 116 (2012)
Show Items
Volume: 115 (2011)
Show Items
Volume: 114 (2011)
Show Items
Volume: 113 (2010)
Show Items
Volume: 112 (2010)
Show Items
Volume: 111 (2009)
Show Items
Volume: 110 (2009)
Show Items
Volume: 109 (2008)
Show Items
Volume: 108 (2008)
Show Items
Volume: 107 (2007)
Show Items
Volume: 106 (2007)
Show Items
Volume: 105 (2006)
Show Items
Volume: 104 (2006)
Show Items
Volume: 103 (2005)
Show Items
Volume: 102 (2005)
Show Items
Volume: 101 (2004)
Show Items
Volume: 100 (2004)
Show Items
Volume: 99 (2003)
Show Items
Volume: 98 (2003)
Show Items
Volume: 97 (2002)
Show Items
Volume: 96 (2002)
Show Items
Volume: 95 (2001)
Show Items
Volume: 94 (2001)
Show Items
Volume: 93 (2000)
Show Items
Volume: 92 (2000)
Show Items
Volume: 91 (1999)
Show Items
Volume: 90 (1999)
Show Items
Volume: 89 (1998)
Show Items
Volume: 88 (1998)
Show Items
Volume: 87 (1997)
Show Items
Volume: 86 (1997)
Show Items
Volume: 85 (1996)
Show Items
Volume: 84 (1996)
Show Items
Volume: 83 (1995)
Show Items
Volume: 82 (1995)
Show Items
Volume: 81 (1994)
Show Items
Volume: 80 (1994)
Show Items
Volume: 79 (1993)
Show Items
Volume: 78 (1993)
Show Items
Volume: 77 (1992)
Show Items
Volume: 76 (1992)
Show Items
Volume: 75 (1991)
Show Items
Volume: 74 (1991)
Show Items
Volume: 73 (1990)
Show Items
Volume: 72 (1990)
Show Items
Volume: 71 (1989)
Show Items
Volume: 70 (1989)
Show Items
Volume: 69 (1988)
Show Items
Volume: 68 (1988)
Show Items
Volume: 67 (1987)
Show Items
Volume: 66 (1987)
Show Items
Volume: 65 (1986)
Show Items
Volume: 64 (1986)
Show Items
Volume: 63 (1985)
Show Items
Volume: 62 (1985)
Show Items
Volume: 61 (1984)
Show Items
Volume: 60 (1984)
Show Items
Volume: 59 (1983)
Show Items
Volume: 58 (1983)
Show Items
Volume: 57 (1982)
Show Items
Volume: 56 (1982)
Show Items
Volume: 55 (1981)
Show Items
Volume: 54 (1981)
Show Items
Volume: 53 (1980)
Show Items
Volume: 52 (1980)
Show Items
Volume: 51 (1979)
Show Items
Volume: 50 (1979)
Show Items
Volume: 49 (1978)
Show Items
Volume: 48 (1978)
Show Items
Volume: 47 (1977)
Show Items
Volume: 46 (1977)
Show Items
Volume: 45 (1976)
Show Items
Volume: 44 (1976)
Show Items
Volume: 43 (1975)
Show Items
Volume: 42 (1975)
Show Items
Volume: 41 (1974)
Show Items
Volume: 40 (1974)
Show Items
Volume: 39 (1973)
Show Items
Volume: 38 (1973)
Show Items
Volume: 37 (1972)
Show Items
Volume: 36 (1972)
Show Items
Volume: 35 (1971)
Show Items
Volume: 34 (1971)
Show Items
Volume: 33 (1970)
Show Items
Volume: 32 (1970)
Show Items
Volume: 31 (1969)
Show Items
Volume: 30 (1969)
Show Items
Volume: 29 (1968)
Show Items
Volume: 28 (1968)
Show Items
Volume: 27 (1967)
Show Items
Volume: 26 (1967)
Show Items
Volume: 25 (1966)
Show Items
Volume: 24 (1966)
Show Items
Volume: 23 (1965)
Show Items
Volume: 22 (1965)
Show Items
Volume: 21 (1964)
Show Items
Volume: 20 (1963)
Show Items
Volume: 19 (1962)
Show Items
Volume: 18 (1961)
Show Items
Volume: 17 (1960)
Show Items
Volume: 16 (1959)
Show Items
Volume: 15 (1958)
Show Items
Volume: 14 (1957)
Show Items
Volume: 13 (1956)
Show Items
Volume: 12 (1955)
Show Items
Volume: 11 (1954)
Show Items
Volume: 10 (1953)
Show Items
Volume: 9 (1952)
Show Items
Volume: 8 (1951)
Show Items
Volume: 7 (1950)
Show Items
Volume: 6 (1949)
Show Items
Volume: 5 (1948)
Show Items
Volume: 4 (1947)
Show Items
Volume: 3 (1946)
Show Items
Volume: 2 (1945)
Show Items
Volume: 1 (1944)
Show Items

Contributor Notes

Address reprint requests to: Professor Haruhiko Kikuchi, Department of Neurosurgery, Faculty of Medicine, Kyoto University, 54 Kawahara-cho, Sakyo-ku, Kyoto 606, Japan.
  • 1.

    Abo T, & Balch CM: Characterization of HNK-1+ (Leu-7) human lymphocytes. II. Distinguishing phenotypic and functional properties of natural killer cells from activated NK-like cells. J Immunol 129:1758–1761, 1982 Abo T, Balch CM: Characterization of HNK-1+ (Leu-7) human lymphocytes. II. Distinguishing phenotypic and functional properties of natural killer cells from activated NK-like cells. J Immunol 129:1758–1761, 1982

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Anichini A, , Fossati G, & Parmiani G: Clonal analysis of cytotoxic T-lymphocyte response to autologous human metastatic melanoma. Int J Cancer 35:683–689, 1985 Anichini A, Fossati G, Parmiani G: Clonal analysis of cytotoxic T-lymphocyte response to autologous human metastatic melanoma. Int J Cancer 35:683–689, 1985

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Apuzzo MLJ, & Mitchell MS: Immunobiological aspects of intrinsic glial tumors. J Neurosurg 55:1–18, 1981 Apuzzo MLJ, Mitchell MS: Immunobiological aspects of intrinsic glial tumors. J Neurosurg 55:1–18, 1981

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Brooks WH, , Latta RB, & Mahaley MS, et al: Immunobiology of primary intracranial tumors. Part 5: Correlation of a lymphocyte index and clinical status. J Neurosurg 54:331–337, 1981 Brooks WH, Latta RB, Mahaley MS, et al: Immunobiology of primary intracranial tumors. Part 5: Correlation of a lymphocyte index and clinical status. J Neurosurg 54:331–337, 1981

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Brunner KT, , Engers HD, & Cerottini JC: The 51Cr release assay as used for the quantitative measurement of cell-mediated cytolysis in vitro, in Bloom BR, & David JR (eds): In Vitro Methods in Cell-Mediated and Tumor Immunity. New York: Academic Press, 1976, pp 423–428 Brunner KT, Engers HD, Cerottini JC: The 51Cr release assay as used for the quantitative measurement of cell-mediated cytolysis in vitro, in Bloom BR, David JR (eds): In Vitro Methods in Cell-Mediated and Tumor Immunity. New York: Academic Press, 1976, pp 423–428

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    De Vries JE, & Spitz H: Cloned human cytotoxic lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation and analysis to phenotype and specificity. J Immunol 132:510–519, 1984 De Vries JE, Spitz H: Cloned human cytotoxic lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation and analysis to phenotype and specificity. J Immunol 132:510–519, 1984

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Farrar WL, , Johnson HM, & Farrarr JJ: Regulation of the production of immune interferon and cytotoxic T lymphocytes by interleukin 2. J Immunol 126:1120–1125, 1981 Farrar WL, Johnson HM, Farrarr JJ: Regulation of the production of immune interferon and cytotoxic T lymphocytes by interleukin 2. J Immunol 126:1120–1125, 1981

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Grimm EA, , Mazumder A, & Zhang HZ, et al: Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes. J Exp Med 155:1823–1841, 1982 Grimm EA, Mazumder A, Zhang HZ, et al: Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes. J Exp Med 155:1823–1841, 1982

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Hersey P, , MacDonald M, & Schibeci S, et al: Clonal analysis of cytotoxic T lymphocyte (CTL) against autologous melanoma. Classification based on phenotype, specificity and inhibition by monoclonal antibodies to T cell structures. Cancer Immunol Immunother 22:15–23, 1986 Hersey P, MacDonald M, Schibeci S, et al: Clonal analysis of cytotoxic T lymphocyte (CTL) against autologous melanoma. Classification based on phenotype, specificity and inhibition by monoclonal antibodies to T cell structures. Cancer Immunol Immunother 22:15–23, 1986

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Ibayashi Y, , Uede T, & Uede T, et al: Functional analysis of mononuclear cells infiltrating into tumors: differential cytotoxicity of mononuclear cells from tumors of immune and nonimmune rats. J Immunol 134:648–653, 1985 Ibayashi Y, Uede T, Uede T, et al: Functional analysis of mononuclear cells infiltrating into tumors: differential cytotoxicity of mononuclear cells from tumors of immune and nonimmune rats. J Immunol 134:648–653, 1985

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Kedar E, , Chriqui-Zeira E, & Mitelman S: Methods for amplifying the induction and expression of cytotoxic response in vitro to syngeneic and autologous freshly-isolated solid tumors of mice. Cancer Immunol Immunother 18:126–134, 1984 Kedar E, Chriqui-Zeira E, Mitelman S: Methods for amplifying the induction and expression of cytotoxic response in vitro to syngeneic and autologous freshly-isolated solid tumors of mice. Cancer Immunol Immunother 18:126–134, 1984

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Köhler G, & Milstein C: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495–497, 1975 Köhler G, Milstein C: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495–497, 1975

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Lotze MT, , Grimm EA, & Mazumder A, et al: Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor. Cancer Res 41:4420–4425, 1981 Lotze MT, Grimm EA, Mazumder A, et al: Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor. Cancer Res 41:4420–4425, 1981

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Mazumder A, , Grimm EA, & Rosenberg SA: Characterization of the lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with phytohemagglutinin. J Immunol 130:958–964, 1983 Mazumder A, Grimm EA, Rosenberg SA: Characterization of the lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with phytohemagglutinin. J Immunol 130:958–964, 1983

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Mazumder A, , Grimm EA, & Zhang HZ, et al: Lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with lectins. Cancer Res 42:913–918, 1982 Mazumder A, Grimm EA, Zhang HZ, et al: Lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with lectins. Cancer Res 42:913–918, 1982

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Meuer SC, , Fitzgerald KA, & Hussey RE, et al: Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med 157:705–719, 1983 Meuer SC, Fitzgerald KA, Hussey RE, et al: Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med 157:705–719, 1983

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Meuer SC, , Hussey RE, & Hodgdon JC, et al: Surface structures involved in target recognition by human cytotoxic T lymphocytes. Science 218:471–473, 1982 Meuer SC, Hussey RE, Hodgdon JC, et al: Surface structures involved in target recognition by human cytotoxic T lymphocytes. Science 218:471–473, 1982

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Meuer SC, , Schlossman SF, & Reinhertz EL: Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci USA 79:4395–4399, 1982 Meuer SC, Schlossman SF, Reinhertz EL: Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci USA 79:4395–4399, 1982

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Morantz RA, , Shain W, & Cravioto H: Immune surveillance and tumors of the nervous system. J Neurosurg 49:84–92, 1978 Morantz RA, Shain W, Cravioto H: Immune surveillance and tumors of the nervous system. J Neurosurg 49:84–92, 1978

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Morgan DA, , Ruscetti FW, & Gallo R: Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 193:1007–1008, 1976 Morgan DA, Ruscetti FW, Gallo R: Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 193:1007–1008, 1976

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21.

    Mukherji B, & MacAlister TJ: Clonal analysis of cytotoxic T cell response against human melanoma. J Exp Med 158:240–245, 1983 Mukherji B, MacAlister TJ: Clonal analysis of cytotoxic T cell response against human melanoma. J Exp Med 158:240–245, 1983

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22.

    Plata F: Specificity studies of cytolytic T lymphocytes directed against murine leukemia virus-induced tumors: analysis by monoclonal cytolytic T lymphocytes. J Exp Med 155:1050–1062, 1982 Plata F: Specificity studies of cytolytic T lymphocytes directed against murine leukemia virus-induced tumors: analysis by monoclonal cytolytic T lymphocytes. J Exp Med 155:1050–1062, 1982

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23.

    Reinherz EL, , Kung PC, & Goldstein G, et al: A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2. J Immunol 124:1301–1307, 1980 Reinherz EL, Kung PC, Goldstein G, et al: A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2. J Immunol 124:1301–1307, 1980

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Reinherz EL, , Kung PC, & Goldstein G, et al: Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci USA 76:4061–4065, 1979 Reinherz EL, Kung PC, Goldstein G, et al: Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci USA 76:4061–4065, 1979

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Reinherz EL, & Schlossman SF: The differentiation and function of human T lymphocytes. Cell 19:821–827, 1980 Reinherz EL, Schlossman SF: The differentiation and function of human T lymphocytes. Cell 19:821–827, 1980

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Rosenberg SA, , Grimm EA, & McGrogan M, et al: Biological activity of recombinant human interleukin-2 produced in Escherichia coli. Science 223:1412–1415, 1984 Rosenberg SA, Grimm EA, McGrogan M, et al: Biological activity of recombinant human interleukin-2 produced in Escherichia coli. Science 223:1412–1415, 1984

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Rosenberg SA, , Lotze MT, & Muul LM, et al: Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med 313:1485–1492, 1985 Rosenberg SA, Lotze MT, Muul LM, et al: Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med 313:1485–1492, 1985

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    Rutka JT, , Giblin JR, & Høifødt HK, et al: Establishment and characterization of a cell line from a human gliosarcoma. Cancer Res 46:5893–5902, 1986 Rutka JT, Giblin JR, Høifødt HK, et al: Establishment and characterization of a cell line from a human gliosarcoma. Cancer Res 46:5893–5902, 1986

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29.

    Ryser JE, , Cerottini JC, & Brunner KT: Generation of cytolytic T lymphocytes in vitro. IX. Induction of secondary CTL responses in primary long-term MLC by supernatants from secondary MLC. J Immunol 120:370–377, 1978 Ryser JE, Cerottini JC, Brunner KT: Generation of cytolytic T lymphocytes in vitro. IX. Induction of secondary CTL responses in primary long-term MLC by supernatants from secondary MLC. J Immunol 120:370–377, 1978

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 30.

    Sato T, , Sato N, & Takahashi S, et al: Specific cytotoxicity of a long-term cultured T-cell clone on human autologous mammary cancer cells. Cancer Res 46:4384–4389, 1986 Sato T, Sato N, Takahashi S, et al: Specific cytotoxicity of a long-term cultured T-cell clone on human autologous mammary cancer cells. Cancer Res 46:4384–4389, 1986

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    Spits H, , Ijssel H, & Terhorst C, et al: Establishment of human T lymphocyte clones highly cytotoxic for an EBV-transformed B cell line in serum-free medium: isolation of clones that differ in phenotype and specificity. J Immunol 128:95–99, 1982 Spits H, Ijssel H, Terhorst C, et al: Establishment of human T lymphocyte clones highly cytotoxic for an EBV-transformed B cell line in serum-free medium: isolation of clones that differ in phenotype and specificity. J Immunol 128:95–99, 1982

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 32.

    Stejskal V, , Lindberg S, & Holm G, et al: Differential cytotoxicity of activated lymphocytes on allogeneic and xenogeneic target cells. II. Activation by phytohemagglutinin. Cell Immunol 8:82–92, 1973 Stejskal V, Lindberg S, Holm G, et al: Differential cytotoxicity of activated lymphocytes on allogeneic and xenogeneic target cells. II. Activation by phytohemagglutinin. Cell Immunol 8:82–92, 1973

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 33.

    Taniguchi T, , Matsui H, & Fujita T, et al: Structure and expression of cloned cDNA for human interleukin-2. Nature 302:305–310, 1983 Taniguchi T, Matsui H, Fujita T, et al: Structure and expression of cloned cDNA for human interleukin-2. Nature 302:305–310, 1983

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 34.

    Ting CC, , Hargrove ME, & Stephany D: Generation of activated killer cells in tumor-bearing hosts. Int J Cancer 39:232–239, 1987 Ting CC, Hargrove ME, Stephany D: Generation of activated killer cells in tumor-bearing hosts. Int J Cancer 39:232–239, 1987

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35.

    Ting CC, , Rodrigues D, & Ting RC, et al: Suppression of T cell-mediated immunity by tumor cells: immunogenicity versus immunosuppression and preliminary characterization of the suppressive factors. Int J Cancer 24:644–655, 1979 Ting CC, Rodrigues D, Ting RC, et al: Suppression of T cell-mediated immunity by tumor cells: immunogenicity versus immunosuppression and preliminary characterization of the suppressive factors. Int J Cancer 24:644–655, 1979

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 36.

    Vose BM, , Riccardi C, & Bonnard GD, et al: Limiting dilution analysis of the frequency of human T cells and large granular lymphocytes proliferating in response to interleukin 2. II. Regulatory role of interferon on proliferative and cytotoxic precursors. J Immunol 130:768–772, 1983 Vose BM, Riccardi C, Bonnard GD, et al: Limiting dilution analysis of the frequency of human T cells and large granular lymphocytes proliferating in response to interleukin 2. II. Regulatory role of interferon on proliferative and cytotoxic precursors. J Immunol 130:768–772, 1983

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 37.

    Wikstrand CJ, & Bigner DD: Immunobiologic aspects of the brain and human gliomas. A review. Am J Pathol 98:517–567, 1980 Wikstrand CJ, Bigner DD: Immunobiologic aspects of the brain and human gliomas. A review. Am J Pathol 98:517–567, 1980

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 38.

    Yamasaki T, , Handa H, & Yamashita J, et al: Specific adoptive immunotherapy with tumor-specific cytotoxic T-lymphocyte clone for murine malignant gliomas. Cancer Res 44:1776–1783, 1984 Yamasaki T, Handa H, Yamashita J, et al: Specific adoptive immunotherapy with tumor-specific cytotoxic T-lymphocyte clone for murine malignant gliomas. Cancer Res 44:1776–1783, 1984

    • PubMed
    • Search Google Scholar
    • Export Citation

Metrics

All Time Past Year Past 30 Days
Abstract Views 595 314 3
Full Text Views 140 0 0
PDF Downloads 89 0 0
EPUB Downloads 0 0 0