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Mononuclear cell infiltration in central portions of human astrocytomas

Edward R. Hitchcock Department of Neurosurgery, University of Birmingham, Midland Centre for Neurosurgery and Neurology, Birmingham, England

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 F.R.C.S., M.Sc.
and
Christine S. Morris Department of Neurosurgery, University of Birmingham, Midland Centre for Neurosurgery and Neurology, Birmingham, England

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Page Range:
432–437
Volume/Issue:
Volume 68: Issue 3
DOI link:
https://doi.org/10.3171/jns.1988.68.3.0432
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✓ The mononuclear cell infiltration in the central portion of human low- and high-grade astrocytomas has been examined using monoclonal antibodies to cell surface differentiation antigens. There was no significant difference between the number of T cells, B cells, or macrophages. The OKT8+ (suppressor/cytotoxic) T cell population was the major lymphocyte subset in the infiltrates. There was, however, indirect evidence for a proportion of the total OKT8+ cells being natural killer cells. Overall, there was a significant difference in the number of macrophages compared to the total lymphoid cell population. Several cell types seem to play an equal role in the cellular and humoral immune response within the center of the tumors, as distinct from that occurring at the periphery.

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Contributor Notes

Address reprint requests to: Edward R. Hitchcock, F.R.C.S., Department of Neurosurgery, Midland Centre for Neurosurgery and Neurology, Holly Lane, Smethwick, Warley, West Midlands B67 7JX, England.
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