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Cell adhesion molecules in Alzheimer's disease
Received 1 February 2012
Accepted for publication 24 March 2012
Published 5 July 2012 Volume 2012:2 Pages 65—77
DOI https://doi.org/10.2147/DNND.S19829
Review by Single anonymous peer review
Peer reviewer comments 3
Malin Wennström, Henrietta M Nielsen
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
Abstract: Cell adhesion molecules (CAMs) mediate interactions between cells and their surroundings that are vital to processes controlling for cell survival, activation, migration, and plasticity. However, increasing evidence suggests that CAMs also mediate mechanisms involved in several neurological diseases. This article reviews the current knowledge on the role of CAMs in amyloid-ß (Aß) metabolism, cell plasticity, neuroinflammation, and vascular changes, all of which are considered central to the pathogenesis and progression of Alzheimer's disease (AD). This paper also outlines the possible roles of CAMs in current and novel AD treatment strategies.
Keywords: cell adhesion molecules, Alzheimer's disease, neuroinflammation, plasticity, amyloid-beta, vascular changes
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