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Local estrogen biosynthesis in males and females.

in Endocrine-Related Cancer
Authors:
E Simpson Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia.

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G Rubin Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia.

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C Clyne Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia.

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K Robertson Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia.

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L O'Donnell Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia.

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S Davis Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia.

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M Jones Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia.

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Volume/Issue:
Volume 6: Issue 2
Article Type:
Abstract
Page Range:
131–137
Online Publication Date:
Jun 1999
Free access

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It is now apparent that in men and in postmenopausal women, estrogens have important physiological and pathophysiological roles. However, importantly, these actions are at a local level, namely paracrine, autocrine, and even 'intracrine' rather than endocrine in the classical sense. Thus for example local estrogen biosynthesis in the bones of men plays a hitherto unsuspected role in the maintenance of bone mineralization and in epiphyseal fusion; and in the testes, estrogen is essential for male germ cell development. On the other hand, in postmenopausal women, the mesenchymal cells of the breast are the major source of estrogen responsible for breast cancer development. This realization points to the importance of circulating C19 precursors in the maintenance of adequate estrogen biosynthesis in extragonadal sites and suggests the possibility of new therapies to block estrogen synthesis in a tissue-specific fashion.

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Sept 2018 onwards Past Year Past 30 Days
Full Text Views 874 396 39
PDF Downloads 492 204 24

 

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Print ISSN:
1351-0088
Online ISSN:
1479-6821
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Page(s):
7
Print Publication Date:
01 Jan 1999
Online Publication Date:
Jun 1999