Distinct Viral and Mutational Spectrum of Endemic Burkitt Lymphoma
Fig 3
(A) The presence of mutations in genes previously described in BL is reported, including MYC (50%), DDX3X (35%), ID3 (30%), ARID1A (25%), RHOA (20%), TCF3 and TP53 (15%), and CCND3 1/20 (5%). In addition, a new mutation is shown, involving CCNF and detected in 20% of the cases. (B) Bar plot showing the frequency comparison of virus presence and driver mutations between endemic and sporadic BL. For each comparison we report the p-value associated with rejecting the null hypothesis of equal eBL and sBL prevalences. (C) Distribution of mutations in 5 driver genes. Red points indicate endemic BL, while blue points the sporadic ones.