General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels
Fig 5
Anesthetic effect on mitochondrial ATP synthesis.
Time course of ATP synthesis by mitochondria with or without anesthetics (n = 3). Mitochondrial ATP synthesis was measured using the MASC assay [21]. Colors are the same as in Fig 4; control (black), 0.3% IF (red), 0.1% 1PP (blue), and 0.05% PBNa (green). We used 10 μg/ml oligomycin as a control inhibitor (purple). Error bars indicate S.D. The results are also summarized in Table 1.