Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population
Fig 2
PKLR coding variants identified in the test populations.
(a) Schematic representation of the PKLR protein, location of catalytically active residues (phosphoenolpyruvate, PEP, binding residues; R116, G338, D339, and T371) and allosteric regulation site (fructose-1,6-bisphosphate, FBP, binding site; loops 475–490 and 557–566, and residue R532) within structural domains [34, 46], and location of non-synonymous mutations identified from sequencing (R41Q, V269F and L272V). (b) Subset of multiple species protein alignment by Clustal Omega (www.ebi.ac.uk) where “*” = single, fully conserved residue; “:” = strongly similar properties