IL-17A Mediates Early Post-Transplant Lesions after Heterotopic Trachea Allotransplantation in Mice
Figure 1
IL-17A deficiency does not prevent obliterative airway disease.
Fully allogeneic BALB/C tracheas were heterotopically grafted into WT or IL-17A-/- C57BL/6 recipients and harvested after 28 days. A, pathologic scores. B & C, histologic analysis of allografts harvested from one representative WT and IL-17A-/- recipient, respectively. Masson’s trichrome staining of a whole section (magnification x40). D, percentages of lumenal fibrosis. The bars represent the mean ± SEM of 12-15 organs in each group. Data are pooled from three independent experiments.