Fingolimod Phosphate Attenuates Oligomeric Amyloid β–Induced Neurotoxicity via Increased Brain-Derived Neurotrophic Factor Expression in Neurons
Figure 1
Neurons express all S1PR subtypes.
(A) Representative RT-PCR data for S1PRs. Neurons constitutively expressed all S1PR subtypes regardless of oAβ–stimulation. (B) Immunostaining data for S1PRs in untreated neurons. Neurons constitutively expressed all S1PR subtypes. Scale bar, 20 µm. (C) Western blotting data for S1PRs. Arrowheads indicate the bands for S1PRs. Neurons constitutively expressed all S1PR subtypes regardless of oAβ–stimulation. NT, no treatment; oA 5 µM oAβ1-42 treatment. The positive control samples used for each S1PR were as follows; brain for S1P1 and S1P3; heart for S1P2; spleen for S1P4 and S1P5.