Pericytes Regulate Vascular Basement Membrane Remodeling and Govern Neutrophil Extravasation during Inflammation
Figure 10
Relaxation of pericytes facilitates PMN transmigration in vitro.
(A) Pericyte engagement with PMA-activated PMNs enhanced PMN passage across a pericyte monolayer. n = 5. Note: Due to strong adhesion to the pericytes and the filters, migration of PMA-activated PMNs toward IL-8 in the lower chamber was less than that of control PMNs (See the first two bars). (B) PMN transmigration through a pericyte monolayer in the presence of agents that affect pericyte contractility. n = 4. *P<0.05 and **P<0.01 as indicated.