Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain
Figure 3
Molecular dynamics simulations of the SRA domain in complex with 5mC and 5hmC containing DNA.
(A+B) Three and two-dimensional schematic drawings summarizing the hydrogen bond networks between the nucleotides, the SRA binding pocket, and a conserved water molecule during the simulations. The numbers in (B) correspond to the numbering in (C+D). (C+D) Hydrogen bond occurrences during the molecular dynamics simulations of the SRA domain in complex with either 5mC (C) or 5hmC containing DNA (D). Each vertical line represents a single observed hydrogen bond. The hydrogen bond between 5hmC and the conserved water is highlighted in red.