Cpd-1 Null Mice Display a Subtle Neurological Phenotype
Figure 2
Analysis of motor deficits in CPD1 null mice.
A. Accelerating rotarod analysis: 4 month old CPD1 +/+ (n = 6) and CPD1 −/− (n = 12) were tested for a fall from a rotating rod. Average of 4 trails on each day is plotted. Error bars = SEM; p = 0.067, suggesting no significant changes. B. Dowel test: 4 month old CPD1 null mice require more time to traverse a balance beam. CPD1 +/+ (n = 6) and CPD1−/− (n = 12) were made to traverse a beam placed on two platforms for 8 trials on 8 days. CPD1−/− mice took longer time to traverse the beam (p<0.005). C. CPD1 null mice display clasping behavior. CPD1 +/+ (n = 3) and CPD1 −/− (n = 16) were held from their tails and tested for clasping of the limbs. CPD1 null mice clasp their limbs more times and for longer duration than age matched control (p<0.005).