S100A7, a Novel Alzheimer's Disease Biomarker with Non-Amyloidogenic α-Secretase Activity Acts via Selective Promotion of ADAM-10
Figure 8
In situ S100A7 receptor binding activities in primary embryonic cortical neurons derived from Tg2576 mice, CHO-APPswe cells, and mouse brain.
Seven-day-old Tg2576 neuronal cultures (A), CHO-APPswe cells (B) and 10 µm frozen tissue sections from mouse brain (C) were incubated with AP-S100A7 fusion protein or control AP protein. Blue (A) and purple (B, C) staining detects interaction between AP-S100A7 with a putative S100A7 receptor. Length bar = 10 µm. n = 3 independent cultures per group from two independent experiments.