Allele-specific mitochondrial stress induced by Multiple Mitochondrial Dysfunctions Syndrome 1 pathogenic mutations modeled in Caenorhabditis elegans
Fig 6
Antioxidant treatment partially suppresses the nfu-1 phenotype.
(A) Kaplan-Meier survival curve of nfu-1 mutants with either Veh. (H2O) or NAC treatment (n = 58–60). Detailed statistical analysis presented in Table 3. (B-B”) Fecundity assays following treatment with Veh. (H2O) or NAC (n = 9–10). (B) Total brood size. (B’) Embryonic viability. No statistical differences between treated and untreated. B-B’: Analysis by parallel two-tailed Student’s T-test with Holm-Sidak correction for multiple comparisons. Veh.: Vehicle; NAC: N-acetyl-L-cysteine.