Whole Genome, Whole Population Sequencing Reveals That Loss of Signaling Networks Is the Major Adaptive Strategy in a Constant Environment
Figure 7
A model for adaptive strategy in the constant, glucose-limited environment of the chemostat.
The accumulation of beneficial mutations disruptive of signaling networks leads to the decoupling of sensing from response and the loss of environmental sensitivity. Loss of control of cAMP/PKA pathway function eliminates some of the normal checks required to pass START A, likely to a shortened G1 and constitutive cell division. Likewise, loss of repressors of glucose transporter transcription leads to their constitutive activation, likely enabling the cell to sequester more glucose, leading to increased growth and division.