Phylogenetic Quantification of Intra-tumour Heterogeneity
Figure 4
MEDICC improves reconstruction accuracy over competing methods.
A) Simulations results show the improvement of reconstruction accuracy for MEDICC over naive methods (BioNJ clustering on Euclidean distances between copy-number profiles, red) and competing algorithms (TuMult, green). B) Allele phasing accuracy across the simulated trees. On average 92.9% of all genomic loci were correctly assigned to the individual parental alleles. C) Density estimates of clonal expansion indices for neutrally evolving trees (red) and trees with induced long branches as created by clonal expansion processes (blue) show the ability of MEDICC to detect clonal expansion.