Tuning the Mammalian Circadian Clock: Robust Synergy of Two Loops
Figure 4
Bmal is regulated by the antagonistic action of REV-ERB and ROR.
Represented are in silico expression profiles for the nuclear protein REV-ERBN and RORN, and for Bmal RNA. The nuclear proteins RORN (red) and REV-ERBN (blue) recognize and compete for the cis-regulatory elements in the Bmal (green) promoter region to act, respectively, as positive and negative drivers of Bmal expression.