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Antibiotics Prophylaxis for Operative Hysteroscopy: A Multicenter Randomized Controlled Clinical Study

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Abstract

Objective: To evaluate the incidence of infectious complications and effect of prophylactic antibiotic administration during operative hysteroscopic procedures. Methods: A multicentric randomized controlled trial was conducted between January 2012 and December 2013. Women (n = 180) affected by endometrial hyperplasia, myomas, or endometrial polyps undergoing operative hysteroscopy were randomized to receive cefazolin 2 g intravenously 30 minutes prior to the procedure (n = 91) and no treatment (n = 89). Results: No statistical difference in terms of postoperative fever (2.4% vs 2.3%, P = .99), endometritis (0% vs 0%), pain (6.0% vs 10.4%, P = .40), cervicitis-vaginitis (0% vs 0%), pelvic abscess (0% vs 0%), pelvic inflammatory disease (0% vs 0%), and bleeding (0% vs 0%) was noticed. No statistical difference in terms of side effects attributable to antibiotic prophylaxis such as allergy (0% vs 4.8%, P = .12), nausea (10.7% vs 17.4%, P = .27), vomiting (3.6% vs 4.6%, P = .99), diarrhea (4.8% vs 5.4%, P = .99), cephalea (9.5% vs 3.5%, P = .13), dizziness (4.8% vs 2.3%, P = .44), and meteorism (5.4% vs 3.4%, P = .99) was noticed. Conclusion: The results of the current study support the recommendation not to prescribe routine antibiotic prophylaxis prior to operative hysteroscopy.

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Authors and Affiliations

  1. Department of Gynecology, Obstetrics, and Urology, Sapienza University of Rome, Viale Del Policlinico, 00155, Rome, Italy

    Ludovico Muzii MD, Violante Di Donato MD, PhD, Terenzio Boni MD, Ludovica Imperiale MD, Caterina De Medici MD & Pierluigi Benedetti Panici MD

  2. Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy

    Raffaele Gaglione MD & Riccardo Marana MD

  3. Arbor Vitae Center for Endoscopic Gynecology, Clinica Nuova Villa Claudia, Rome, Italy

    Ivan Mazzon MD

  4. Department of Obstetrics and Gynecology, University of Rome Campus Bio-Medico, Rome, Italy

    Alfonso Ruggiero MD

Authors
  1. Ludovico Muzii MD
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  2. Violante Di Donato MD, PhD
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  3. Terenzio Boni MD
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  4. Raffaele Gaglione MD
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  5. Riccardo Marana MD
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  6. Ivan Mazzon MD
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  7. Ludovica Imperiale MD
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  8. Caterina De Medici MD
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  9. Alfonso Ruggiero MD
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  10. Pierluigi Benedetti Panici MD
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Corresponding author

Correspondence to Violante Di Donato MD, PhD.

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Muzii, L., Donato, V.D., Boni, T. et al. Antibiotics Prophylaxis for Operative Hysteroscopy: A Multicenter Randomized Controlled Clinical Study. Reprod. Sci. 24, 534–538 (2017). https://doi.org/10.1177/1933719116660848

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