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The virulence factors of Mycobacterium tuberculosis: Genetic control, new conceptions

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Abstract

The problem of Mycobacterium tuberculosis virulence, together with drug resistance, is becoming key for the design of drugs with a new mechanism of action and the production of modern concepts and tuberculosis treatment schemes. The review describes gene complexes and their products, including mycolic acids and global regulatory systems at the level of transcriptional, translational, and post-translational modification, etc. The criteria for selection of virulence/pathogenicity factors that might be used for comparative genomic analysis of strains differing in the degree of virulence were recommended. The experimental approaches and test systems for an adequate estimation of the virulence degree of different strains of M. tuberculosis were analyzed.

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  1. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia

    A. A. Prozorov, I. A. Fedorova, O. B. Bekker & V. N. Danilenko

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  1. A. A. Prozorov
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  2. I. A. Fedorova
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  3. O. B. Bekker
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  4. V. N. Danilenko
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Original Russian Text © A.A. Prozorov, I.A. Fedorova, O.B. Bekker, V.N. Danilenko, 2014, published in Genetika, 2014, Vol. 50, No. 8, pp. 885–908.

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Prozorov, A.A., Fedorova, I.A., Bekker, O.B. et al. The virulence factors of Mycobacterium tuberculosis: Genetic control, new conceptions. Russ J Genet 50, 775–797 (2014). https://doi.org/10.1134/S1022795414080055

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