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Role of NUDIX Hydrolases in NAD and ADP-Ribose Metabolism in Mammals

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Abstract

Proteins of the NUDIX hydrolase (NUDT) superfamily that cleave organic pyrophosphates are found in all classes of organisms, from archaea and bacteria to higher eukaryotes. In mammals, NUDTs exhibit a wide range of functions and are characterized by different substrate specificity and intracellular localization. They control the concentration of various metabolites in the cell, including key regulatory molecules such as nicotinamide adenine dinucleotide (NAD), ADP-ribose, and their derivatives. In this review, we discuss the role of NUDT proteins in the metabolism of NAD and ADP-ribose in human and animal cells.

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Abbreviations

ADPR:

ADP-ribose

AMPK:

AMP-activated protein kinase

ANT:

adenine nucleotide translocase

ARH:

ADP-ribosylhydrolase

cADPR:

cyclic ADP-ribose

ER:

endoplasmic reticulum

Nam:

nicotinamide

NAD:

nicotinamide adenine dinucleotide

NADP:

nicotinamide adenine dinucleotide phosphate

NMN:

nicotinamide mononucleotide

NMNAT:

nicotinamide mononucleotide adenylyltransferase

NUDT:

NUDIX hydrolase

OAcADPR:

O-acetyl-ADP-ribose

PARP:

poly(ADP-ribose) polymerase

PAR:

poly(ADP-ribose)

PARG:

poly(ADP-ribose) glycohydrolase

R5′P:

ribose 5′-phosphate

ROS:

reactive oxygen species

TARG:

terminal ADP-ribose protein glycohydrolase 1

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Funding

This work was supported by the Russian Science Foundation (project no. 18-74-00081) and Russian Foundation for Basic Research (project no. 19-34-60039).

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  1. Peter the Great St. Petersburg Polytechnic University, 195251, Saint Petersburg, Russia

    V. A. Kulikova

  2. Institute of Cytology, Russian Academy of Sciences, 194064, Saint Petersburg, Russia

    V. A. Kulikova & A. A. Nikiforov

  3. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223, Saint Petersburg, Russia

    V. A. Kulikova

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  1. V. A. Kulikova
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Kulikova, V.A., Nikiforov, A.A. Role of NUDIX Hydrolases in NAD and ADP-Ribose Metabolism in Mammals. Biochemistry Moscow 85, 883–894 (2020). https://doi.org/10.1134/S0006297920080040

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