Satellite Cell Activation in Human Skeletal Muscle After Training: Evidence for Muscle Fiber Neoformation

H.-J. Appell; S. Forsberg; W. Hollmann

doi:10.1055/s-2007-1025026

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Int J Sports Med 1988; 09(4): 297-299
DOI: 10.1055/s-2007-1025026

Short Communication

Satellite Cell Activation in Human Skeletal Muscle After Training: Evidence for Muscle Fiber Neoformation

H.-J. Appell¹ , S. Forsberg² , W. Hollmann²

¹1nstitute for Experimental Morphology
²Institute for Cardiology and Sports Medicine, German Sports University, Cologne, F. R. Germany

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Publication History

Publication Date:
14 March 2008 (online)

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Abstract

In subjects who had undergone monopedal bicycle ergometer work for 30 min 4 days a week for 6 weeks under aerobic conditions, biopsies from the M. vastus lateralis were studied in the light and electron microscope. In some cases very small myofibers with central nuclei were found. At the ultrastructural level, these fibers turned out to be myotubes. The satellite cells occasionally appeared to be activated and to fuse with muscle fibers. It was concluded that these observations represented evidence for the development of new muscle fibers.

Key words

skeletal muscle - man - training - hyperplasia - satellite cell