Issue 3, 2011
From the journal:

Chemical Society Reviews

Targeting the protein–protein interactions of the HIV lifecycle

Ali Tavassolia  

a University of Southampton, Southampton, UK
E-mail: a.tavassoli@soton.ac.uk
Web: http://www.personal.soton.ac.uk/ali1

Abstract

The human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), relies heavily on protein–protein interactions in almost every step of its lifecycle. Targeting these interactions, especially those between virus and host proteins, is increasingly viewed as an ideal avenue for the design and development of new therapeutics. In this tutorial review, we outline the lifecycle of HIV and describe some of the protein–protein interactions that control and regulate each step of this process, also detailing efforts to develop therapies that target these interactions.

Graphical abstract: Targeting the protein–protein interactions of the HIV lifecycle

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Article information

DOI
https://doi.org/10.1039/C0CS00092B
Article type
Tutorial Review
Submitted
27 Aug 2010
First published
10 Dec 2010

Chem. Soc. Rev., 2011,40, 1337-1346

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Targeting the protein–protein interactions of the HIV lifecycle

A. Tavassoli, Chem. Soc. Rev., 2011, 40, 1337 DOI: 10.1039/C0CS00092B

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