Issue 2, 2005
From the journal:

Molecular BioSystems

Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections

Zuben E. Sauna,a   Suneet Shuklaa  and  Suresh V. Ambudkar*a  

* Corresponding authors

a Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, Maryland
E-mail: ambudkar@helix.nih.gov
Fax: (301) 435-8188
Tel: (301) 402-4178

Abstract

Disulfiram, a drug used to treat alcoholism, has recently been indicated to play a primary as well as an adjuvant role in the treatment of many cancers and in the reversal of fungal drug-resistance. This review discusses the molecular mechanism of action of disulfiram and its potential use in the treatment of human cancers and fungal infections.

Graphical abstract: Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections

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Article information

DOI
https://doi.org/10.1039/B504392A
Article type
Review Article
Submitted
30 Mar 2005
Accepted
16 May 2005
First published
26 May 2005

Mol. BioSyst., 2005,1, 127-134

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Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections

Z. E. Sauna, S. Shukla and S. V. Ambudkar, Mol. BioSyst., 2005, 1, 127 DOI: 10.1039/B504392A

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