* Corresponding authors

^a Prairie Plant Systems Inc, Botanical Alternatives Inc, Suite 176, 8B-3110 8th Street E, Saskatoon, SK, Canada

^b Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK

^c Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany

^d Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy University of North Carolina, Chapel Hill, NC 27599, USA

^e Pharmaceutical Sciences Division, University of Wisconsin-Madison, Wisconsin, USA

^f Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, USA

^g Department of Pharmacology and Pharmaceutical Sciences & Department of Chemistry, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA

^h School of Chemistry, EaStCHEM, University of Edinburgh, West Mains Road, Edinburgh, UK

ⁱ Department of Chemistry, University of Warwick, Coventry, United Kingdom

^j Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA

^k Teagasc Food Research Centre, Moorepark, Fermoy, Co. and Alimentary Pharmabiotic Centre, Cork, Ireland

^l Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia

^m Novacta Biosystems Ltd, UH Innovation Centre, College Lane, Hatfield, Herts AL10 9AB, United Kingdom

ⁿ University of Potsdam, Institute for Biochemistry and Biology, Karl-Liebknecht-Str. 24/25, 14476 Potsdam-Golm, Germany

^o NAICONS Scrl, Via G. Fantoli 16/15, 20138 Milan, Italy

^p Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093, USA

^q Institute Molecular Biosciences, Excellence Cluster: Macromolecular Complexes, Goethe University Frankfurt, Max-von-Laue Str. 9, 60438 Frankfurt/M., Germany

^r Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, California 94158, USA

^s Center for Bioinformatics & Computational Biology, Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way, Suite 205, Newark, DE 19711-5449, USA

^t Division of Pharmacognosy, Dept Medicinal Chemistry, Uppsala University, BMC Box 574, SE 75123 Uppsala, Sweden

^u Medical University of Vienna, Center for Physiology and Pharmacology, Schwarzspanierstr.17, A-1090 Vienna, Austria

^v J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, Maryland 20850, USA

^w Department of Chemistry, University of Hawai'i at Manoa, 2545 McCarthy Mall, Honolulu, HI 96822-2275, USA

^x Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstr. 11a, 07745 Jena, Germany

^y Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Ireland

^z Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA

^aa Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland, UK

^ab School of Chemistry and Biochemistry and the Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA

^ac Department of Chemistry, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA

^ad Molecular Genetics, University of Groningen, Nijenborgh 7, Groningen, The Netherlands

^ae Department of Chemical and Biological Engineering, A207 Engineering Quadrangle, Princeton University, Princeton, New Jersey 08544, USA

^af State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

^ag Fachbereich Chemie/Biochemie der Philipps Universität Marburg, Hans-Meerwein-Str., D-35032 Marburg, Germany

^ah Departments of Chemistry and Microbiology and the Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

^ai Lanthiopharma, Nijenborgh 4, 9747 AG Groningen, The Netherlands

^aj Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

^ak Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infectious Research (HZI), Department Microbial Natural Products, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany

^al Department of Biochemistry, Center for Biophysics and Computational Biology, University of Illinois, 600 S. Mathews Ave, Urbana, IL 61801, USA

^am Laboratory of Microbial Gene Technology Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Biotechnology Building, N1432 Aas, Norway

^an Institute of Molecular BioSciences, Massey University, Private Bag 11222, Palmerston North, New Zealand

^ao Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA

^ap Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan

^aq Institute of Molecular BioSciences, Massey University, Private Bag 11222, Palmerston North, New Zealand

^ar Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany

^as Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Wolfgang-Pauli-Str. 10, 8093 Zurich, Switzerland

^at Department of Plant Sciences, University of Saskatchewan, Saskatoon, SK, Canada

^au Laboratory of Communication Molecules and Adaptation of Microorganisms, Muséum National d’Histoire Naturelle, Paris, France

^av Teagasc Food Research Centre, Moorepark, Fermoy, Co., and Alimentary Pharmabiotic Centre, Cork, Ireland

^aw University of Bonn, Institute for Medical Microbiology, Immunology and Parasitology, Pharmaceutical Microbiology Section, Meckenheimer Allee 168, D-53115 Bonn, Germany

^ax Department of Medicinal Chemistry and Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA

^ay Department of Pathology, Keck School of Medicine of USC, 2011 Zonal Ave., HMR 204, Los Angeles, California 90033, USA

^az Waksman Institute, Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA

^ba Departments of Chemistry and Molecular Therapeutics, The Natural Products Library Initiative at the Scripps Research Institute, The Scripps Research Institute, 130 Scripps Way, #3A1, Jupiter, Florida 33458, USA

^bb Department of Applied Chemistry and Microbiology, University of Helsinki, P.O. Box 56, Viikki Biocenter, 00014 Helsinki, Finland

^bc Department of Biological Sciences, Texas A&M University, College Station, TX 77843, USA

^bd Institute of Molecular Biotechnology, Department of Chemistry, University of Aalen, 73430 Aalen, Germany

^be Technische Universität Berlin, Fakultät II—Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany

^bf BLIS Technologies Limited Level 1, Centre for Innovation, 87 St David Street, PO Box 56, Dunedin 9054, New Zealand

^bg State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

^bh Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

^bi Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

^bj Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA

^bk Department of Energy, Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA

^bl Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infectious Research (HZI), Department Microbial Natural Products, Saarland University, , Campus C2 3, 66123 Saarbrücken, Germany

^bm Department of Biology and Science Education, Hofstra University-North Shore/LIJ, School of Medicine, Hempstead, New York 11549, USA

^bn Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana–Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA