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The Id proteins and angiogenesis

Oncogene volume 20, pages 8334–8341 (2001)Cite this article

Abstract

Since the identification of the Id proteins over a decade ago, a great many cell cycle and cell fate decisions have been shown to be under the control of these proteins as described in other sections of this review issue. Perhaps the most unsuspected activity of this class of proteins has been their essential role in angiogenesis, both in the forebrain during development and during the growth and metastasis of tumors in adults. This section of the review issue will focus on the key observations which have led to these conclusions, speculations about potential mechanisms and the outlook for potential therapeutic interventions.

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Acknowledgements

Dr R Benezra is supported by a grant from the Breast Cancer Research Foundation. Dr S Rafii is supported by the American Cancer Society and The Leukemia and Lymphoma Society. Dr D Lyden is supported by a grant from Doris Duke Charitable Foundation.

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Authors and Affiliations

  1. Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA

    David Lyden

  2. Department of Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA

    Robert Benezra & David Lyden

  3. Department of Hematology-Oncology, Cornell University Medical College, 1300 York Ave, New York, NY 10021, USA

    Shahin Rafii

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  1. Robert Benezra
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  3. David Lyden
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Correspondence to Robert Benezra.

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Benezra, R., Rafii, S. & Lyden, D. The Id proteins and angiogenesis. Oncogene 20, 8334–8341 (2001). https://doi.org/10.1038/sj.onc.1205160

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