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Tumor necrosis factor receptor-associated factors (TRAFs)

Oncogene volume 20, pages 6482–6491 (2001)Cite this article

Abstract

Tumor necrosis factor receptor-associated factors (TRAFS) were initially discovered as adaptor proteins that couple the tumor necrosis factor receptor family to signaling pathways. More recently they have also been shown to be signal transducers of Toll/interleukin-1 family members. Six members of the TRAF family have been identified. All TRAF proteins share a C-terminal homology region termed the TRAF domain that is capable of binding to the cytoplasmic domain of receptors, and to other TRAF proteins. In addition, TRAFs 2–6 have RING and zinc finger motifs that are important for signaling downstream events. TRAF proteins are thought to be important regulators of cell death and cellular responses to stress, and TRAF2, TRAF5 and TRAF6 have been demonstrated to mediate activation of NF-κB and JNK. TRAF proteins are expressed in normal and diseased tissue in a regulated fashion, suggesting that they play an important role in physiological and pathological processes.

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Acknowledgements

JR Bradley is supported by the National Kidney Research Fund (UK).

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  1. Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK

    John R Bradley

  2. Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

    Jordan S Pober

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Bradley, J., Pober, J. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene 20, 6482–6491 (2001). https://doi.org/10.1038/sj.onc.1204788

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