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TCR SIGNALING

ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination

Nature Immunology volume 23, pages 1293–1294 (2022)Cite this article

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A key biochemical event that enables T cells to discriminate between TCR antigens of varying affinities and to respond only to high-affinity antigens is full activation of the kinase ZAP70.

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Fig. 1: Kinetic proofreading for ligand discrimination by the TCR requires full activation of ZAP70.

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Authors and Affiliations

  1. MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK

    Mahima Swamy

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  1. Mahima Swamy
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Correspondence to Mahima Swamy.

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Swamy, M. ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination. Nat Immunol 23, 1293–1294 (2022). https://doi.org/10.1038/s41590-022-01297-w

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