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Flip-flopping membrane proteins

Nature Structural & Molecular Biology volume 13, pages 94–96 (2006)Cite this article

Some membrane proteins can adopt multiple topologies, forcing us to think more expansively about membrane protein architecture.

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Figure 1: Proposed evolutionary relationships among dual-topology and inverse-topology membrane proteins.
Figure 2: The topology and structure of EmrE and GlpF.

References

  1. Rapp, M., Granseth, E., Seppälä, S. & von Heijne, G. Nat. Struct. Mol. Biol. 13, 112–116 (2006).

    Article  CAS  Google Scholar 

  2. Pornillos, O., Chen, Y.J., Chen, A.P. & Chang, G. Science 310, 1950–1953 (2005).

    Article  CAS  Google Scholar 

  3. Goder, V., Junne, T. & Spiess, M. Mol. Biol. Cell 15, 1470–1478 (2004).

    Article  CAS  Google Scholar 

  4. Bowie, J.U. Nature 438, 581–589 (2005).

    Article  CAS  Google Scholar 

  5. White, S.H. & von Heijne, G. Curr. Opin. Struct. Biol. 14, 397–404 (2004).

    Article  CAS  Google Scholar 

  6. von Heijne, G. & Gavel, Y. Eur. J. Biochem. 174, 671–678 (1988).

    Article  CAS  Google Scholar 

  7. Gafvelin, G. & von Heijne, G. Cell 77, 401–412 (1994).

    Article  CAS  Google Scholar 

  8. Nilsson, I. & von Heijne, G. Cell 62, 1135–1141 (1990).

    Article  CAS  Google Scholar 

  9. Daley, D.O. et al. Science 308, 1321–1323 (2005).

    Article  CAS  Google Scholar 

  10. Ubarretxena-Belandia, I., Baldwin, J.M., Schuldiner, S. & Tate, C.G. EMBO J. 22, 6175–6181 (2003).

    Article  CAS  Google Scholar 

  11. Ubarretxena-Belandia, I. & Tate, C.G. FEBS Lett. 564, 234–238 (2004).

    Article  CAS  Google Scholar 

  12. Ma, C. & Chang, G. Proc. Natl. Acad. Sci. USA 101, 2852–2857 (2004).

    Article  CAS  Google Scholar 

  13. Ninio, S., Elbaz, Y. & Schuldiner, S. FEBS Lett. 562, 193–196 (2004).

    Article  CAS  Google Scholar 

  14. Fu, D. et al. Science 290, 481–486 (2000).

    Article  CAS  Google Scholar 

  15. Pao, G.M. et al. Mol. Microbiol. 5, 33–37 (1991).

    Article  CAS  Google Scholar 

  16. Dutzler, R., Campbell, E.B., Cadene, M., Chait, B.T. & MacKinnon, R. Nature 415, 287–294 (2002).

    Article  CAS  Google Scholar 

  17. Van den Berg, B. et al. Nature 427, 36–44 (2004).

    Article  CAS  Google Scholar 

  18. Yamashita, A., Singh, S.K., Kawate, T., Jin, Y. & Gouaux, E. Nature 437, 215–223 (2005).

    Article  CAS  Google Scholar 

  19. Holthuis, J.C. & Levine, T.P. Nat. Rev. Mol. Cell Biol. 6, 209–220 (2005).

    Article  CAS  Google Scholar 

  20. Zhang, W., Bogdanov, M., Pi, J., Pittard, A.J. & Dowhan, W. J. Biol. Chem. 278, 50128–50135 (2003).

    Article  CAS  Google Scholar 

  21. Crook, M. Blood Coagul. Fibrinolysis 1, 167–174 (1990).

    CAS  PubMed  Google Scholar 

  22. Hegde, R.S. et al. Science 279, 827–834 (1998).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Molecular Biology Institute,

    James U Bowie

  2. UCLA-DOE Institute for Genomics and Proteomics, University of California at Los Angeles, Boyer Hall, 611 Charles E. Young Dr. E., Los Angeles, 90095-1570, California, USA

    James U Bowie

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  1. James U Bowie
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Bowie, J. Flip-flopping membrane proteins. Nat Struct Mol Biol 13, 94–96 (2006). https://doi.org/10.1038/nsmb0206-94

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