The high resolution structure of the new therapeutic target, cathepsin K, complexed with the potent mechanism-based inhibitor, APC3328, reveals the substrate-binding sites of this cysteine proteinase and validates the binding mode for this inhibitor class.
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McGrath, M., Klaus, J., Barnes, M. et al. Crystal structure of human cathepsin K complexed with a potent inhibitor. Nat Struct Mol Biol 4, 105–109 (1997). https://doi.org/10.1038/nsb0297-105
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DOI: https://doi.org/10.1038/nsb0297-105
