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Obesity

Cerebral damage in obesity-associated metabolic syndrome

Nature Reviews Endocrinology volume 10, pages 642–644 (2014)Cite this article

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The prevalence of the metabolic syndrome has increased in tandem with that of obesity. The metabolic syndrome is associated with structural and functional cerebral damage. A new study confirms the association between the metabolic syndrome and reduced brain volume in the absence of diabetes mellitus. Here, we highlight how vascular dysfunction potentially contributes to this brain damage.

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Figure 1: Glucose metabolism in the brain.

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Acknowledgements

The authors acknowledge funding from the NIH (DKDK083537).

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Authors and Affiliations

  1. New York University School of Medicine, 145 East 32nd Street, New York, 10013, NY, USA

    Henry Rusinek & Antonio Convit

  2. Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Building 35, Orangeburg, 10962, NY, USA

    Antonio Convit

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  1. Henry Rusinek
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  2. Antonio Convit
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Correspondence to Antonio Convit.

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The authors declare no competing financial interests.

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Rusinek, H., Convit, A. Cerebral damage in obesity-associated metabolic syndrome. Nat Rev Endocrinol 10, 642–644 (2014). https://doi.org/10.1038/nrendo.2014.141

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