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The power and the promise of oncogene-induced senescence markers

Nature Reviews Cancer volume 6, pages 472–476 (2006)Cite this article

Abstract

Recently, it has been shown that oncogene-induced senescence (OIS) occurs during the early stages of tumorigenesis. Senescent tumour cells are abundant within premalignant neoplastic lesions, whereas they are scarce in malignant tumours. This association of senescence with the premalignant stages of tumour progression opens the possibility of using senescence markers as diagnostic and prognostic tools. Moreover, some chemotherapeutic protocols induce senescence in tumour cells and, consequently, senescence markers could help to monitor treatment response.

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Figure 1: Many roads to senescence.
Figure 2: Senescence in premalignant neoplastic lesions.
Figure 3: Senescence index.

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Acknowledgements

Research at the laboratory of M.S. is funded by the Centro Nacional de Investigaciones Oncológicas (CNIO), the Spanish Ministry of Education and Science, and the European Union (INTACT and PROTEOMAGE projects).

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  1. the Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain

    Manuel Collado & Manuel Serrano

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  1. Manuel Collado
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Correspondence to Manuel Serrano.

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Collado, M., Serrano, M. The power and the promise of oncogene-induced senescence markers. Nat Rev Cancer 6, 472–476 (2006). https://doi.org/10.1038/nrc1884

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