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RAS oncogenes: the first 30 years

Nature Reviews Cancer volume 3, pages 459–465 (2003)Cite this article

A Correction to this article was published on 01 September 2003

Abstract

From the pioneering work with acute transforming retroviruses to the current post-genomic era, RAS genes have always been at the leading edge of signal transduction and molecular oncology. Yet, a complete understanding of RAS function and dysfunction — mainly in human cancer — is still to come. The knowledge that has accumulated since their discovery 30 years ago has, however, been remarkable, and should pave the way for not only solving the outstanding issues regarding RAS biology, but also for developing efficacious drugs that could have a significant impact on cancer treatment.

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Figure 1: Schematic representation of our current view of RAS regulation.
Figure 2: Overview of known RAS effectors and their corresponding biological responses.

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Authors and Affiliations

  1. members of the Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, Madrid, 28029, Spain

    Marcos Malumbres & Mariano Barbacid

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  1. Marcos Malumbres
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  2. Mariano Barbacid
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Correspondence to Marcos Malumbres or Mariano Barbacid.

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DATABASES

Cancer.gov

bladder cancer

colon cancer

lung cancer

pancreatic cancer

GenBank

adenovirus E1A

LocusLink

BRAF

EGF

GRB2

Hras

HRAS

Kras

KRAS

MYC

NF1

Nras

NRAS

PI3K

RAF

RASGRF

SOS1

SOS2

OMIM

neurofibromatosis disease

Saccharomyces Genome Database

CDC25

WormBase

sem-5

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RAS in human disease

Structural biology of RAS

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Malumbres, M., Barbacid, M. RAS oncogenes: the first 30 years. Nat Rev Cancer 3, 459–465 (2003). https://doi.org/10.1038/nrc1097

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