Abstract
Parvalbumin- and cholecystokinin (CCK)-expressing basket cells provide two parallel, functionally distinct sources of perisomatic inhibition to postsynaptic cells. We show that exogenously applied CCK enhances the output from rat parvalbumin-expressing basket cells, while concurrently suppressing GABA release from CCK-expressing neurons through retrograde endocannabinoid action. These results indicate that CCK may act as a molecular switch that determines the source of perisomatic inhibition for hippocampal principal cells.
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References
Freund, T.F. Trends Neurosci. 26, 489–495 (2003).
Wilson, R.I. & Nicoll, R.A. Neuron 31, 453–462 (2001).
Glickfeld, L.L. & Scanziani, M. Nat. Neurosci. 9, 807–815 (2006).
Hefft, S. & Jonas, P. Nat. Neurosci. 8, 1319–1328 (2005).
Földy, C., Neu, A., Jones, M.V. & Soltesz, I. J. Neurosci. 26, 1465–1469 (2006).
Klausberger, T. et al. J. Neurosci. 25, 9782–9793 (2005).
Miller, K.K., Hoffer, A., Svoboda, K.R. & Lupica, C.R. J. Neurosci. 17, 4994–5003 (1997).
Deng, P.Y. & Lei, S. J. Physiol. (Lond.) 572, 425–442 (2006).
Neu, A, Földy, C. & Soltesz, I. J. Physiol. (Lond.) 578, 233–247 (2007).
Wank, S.A. Am. J. Physiol. 269, 628–646 (1995).
Piomelli, D. Nat. Rev. Neurosci. 4, 873–884 (2003).
Chevaleyre, V. & Castillo, P.E. Neuron 38, 461–472 (2003).
Gallopin, T., Geoffroy, H., Rossier, J. & Lambolez, B. Cereb. Cortex 16, 1440–1452 (2006).
Vallebuona, F., Paudice, P. & Raiteri, M. J. Neurochem. 61, 490–495 (1993).
Ravard, S. & Dourish, C.T. Trends Pharmacol. Sci. 11, 271–273 (1990).
Acknowledgements
We thank R. Zhu for technical assistance. This work was supported by the US National Institutes of Health grant NS38580, the Deutsche Forschungsgemeinschaft grant NE1185/1-1 and the George E. Hewitt Foundation for Medical Research.
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Földy, C., Lee, S., Szabadics, J. et al. Cell type–specific gating of perisomatic inhibition by cholecystokinin. Nat Neurosci 10, 1128–1130 (2007). https://doi.org/10.1038/nn1952
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DOI: https://doi.org/10.1038/nn1952
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