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Gene copy number: learning to count past two

Nature Medicine volume 15, pages 1127–1129 (2009)Cite this article

The number of copies of the gene encoding a ligand for an HIV co-receptor have been found to influence the susceptibility to HIV infection and AIDS progression. New studies dispute this conclusion. The studies are contested by the authors of the original findings, and highlight the inherent difficulties in accurately measuring gene copy numbers (pages 1110–1112, 1112–1115, 1115–1117 and 1117–1120).

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Figure 1: Quantifying variation in gene copy number in the CCL3L gene cluster (17q11.2) must contend with at least three types of uncertainty.

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Authors and Affiliations

  1. Sadeep Shrestha and Richard A. Kaslow are in the Department of Epidemiology University of Alabama at Birmingham, Birmingham, Alabama, USA.,

    Sadeep Shrestha & Richard A Kaslow

  2. Jianming 'James' Tang and Richard A. Kaslow are in the Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.,

    Jianming Tang & Richard A Kaslow

Authors
  1. Sadeep Shrestha
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  2. Jianming Tang
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  3. Richard A Kaslow
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Correspondence to Richard A Kaslow.

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Shrestha, S., Tang, J. & Kaslow, R. Gene copy number: learning to count past two. Nat Med 15, 1127–1129 (2009). https://doi.org/10.1038/nm1009-1127

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