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GDF15 and energy balance: homing in on a mechanism

Nature Medicine volume 23, pages 1119–1120 (2017)Cite this article

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Three recent studies in mice have identified a specific receptor, GFRAL, for the known anorectic peptide GDF15. The finding increases mechanistic understanding of its effect and paves the way for the development of novel anti-obesity therapeutics.

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Figure 1: GFRAL is the receptor for GDF15.

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Authors and Affiliations

  1. MRC Metabolic Diseases Unit and Metabolic Research Laboratories, Wellcome Trust–MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital Cambridge, Cambridge, UK

    Irene Cimino, Anthony P Coll & Giles S H Yeo

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  1. Irene Cimino
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  2. Anthony P Coll
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  3. Giles S H Yeo
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Correspondence to Giles S H Yeo.

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Cimino, I., Coll, A. & Yeo, G. GDF15 and energy balance: homing in on a mechanism. Nat Med 23, 1119–1120 (2017). https://doi.org/10.1038/nm.4414

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