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  • Review Article
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Pathogen subversion of cell-intrinsic innate immunity

Nature Immunology volume 8, pages 1179–1187 (2007)Cite this article

An Erratum to this article was published on 01 January 2008

This article has been updated

Abstract

The mammalian immune system has evolved under continuous selective pressure from a wide range of microorganisms that colonize and replicate in animal hosts. A complex set of signaling networks initiate both innate and adaptive immunity in response to the diverse pathogens that mammalian hosts encounter. In response, viral and microbial pathogens have developed or acquired sophisticated mechanisms to avoid, counteract and subvert sensors, signaling networks and a range of effector functions that constitute the host immune response. This balance of host response and pathogen countermeasures contributes to chronic infection in highly adapted pathogens that have coevolved with their host. In this review we outline some of the themes that are beginning to emerge in the mechanisms by which pathogens subvert the early innate immune response.

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Figure 1: Bacterial evasion of TLR detection.
Figure 2: Disruption of innate signaling pathways by microbial proteins.

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  • 17 December 2007

    In the version of this article initially published, some of the reference numbering in the list and text is incorrect, and a reference is missing. The errors have been corrected in the HTML and PDF versions of the article.

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Authors and Affiliations

  1. Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, 06535, Connecticut, USA

    Craig R Roy

  2. Department of Microbiology & Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, 30322, Georgia, USA

    Edward S Mocarski

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Correspondence to Craig R Roy or Edward S Mocarski.

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Roy, C., Mocarski, E. Pathogen subversion of cell-intrinsic innate immunity. Nat Immunol 8, 1179–1187 (2007). https://doi.org/10.1038/ni1528

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