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Notch regulation of lymphocyte development and function

Nature Immunology volume 5, pages 247–253 (2004)Cite this article

Abstract

Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal development. Mammals have four Notch receptors that bind five different ligands. The function of Notch signaling during lymphopoiesis and T cell neoplasia, based on gain-of-function and conditional loss-of-function approaches for the Notch1 receptor, indicates Notch1 is essential in T cell lineage commitment. Recent studies have addressed the involvement of other Notch receptors and ligands as well as their downstream targets, demonstrating additional functions of Notch signaling in embryonic hematopoiesis, intrathymic T cell development, B cell development and peripheral T cell function.

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Figure 1: Notch receptors and signaling.
Figure 2: Notch receptor-ligand expression during hematopoiesis in the mouse.
Figure 3: Notch signaling in lymphopoiesis.

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Acknowledgements

We thank all our colleagues who shared unpublished results with us and apologize to those whose work was not cited because of space limitations. F.R. and S.M. are supported in part by grants from the Swiss Cancer League, the Swiss National Science Foundation, the Leenaards Foundation, the EMBO Young Investigator Program and the Roche Foundation.

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  1. The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, Epalinges, 1066, Switzerland

    Freddy Radtke, Anne Wilson, Stephane J C Mancini & H Robson MacDonald

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Radtke, F., Wilson, A., Mancini, S. et al. Notch regulation of lymphocyte development and function. Nat Immunol 5, 247–253 (2004). https://doi.org/10.1038/ni1045

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