Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Basophils: in the spotlight at last

Nature Immunology volume 9, pages 223–225 (2008)Cite this article

Basophils have long been suspected to be potent inducers of T helper type 2 differentiation. Sokol and colleagues now demonstrate that basophils are required for adoption of the T helper type 2 fate in vivo in response to allergens with protease activity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Model of basophil-mediated TH2 differentiation.

Katie Ris-Vicari

References

  1. Le Gros, G. et al. J. Exp. Med. 172, 921–929 (1990)

    Article  CAS  Google Scholar 

  2. Sokol, C.L., Barton, G.M., Farr, A.G. & Medzhitov, R. Nat. Immunol. 9, 310–318 (2008).

    Article  CAS  Google Scholar 

  3. Chapman, M.D., Wunschmann, S. & Pomes, A. Curr. Allergy Asthma Rep. 7, 363–367 (2007).

  4. Liu, Y.J. et al. Annu. Rev. Immunol. 25, 193–219 (2007).

    Article  CAS  Google Scholar 

  5. Seder, R.A. et al. Proc. Natl. Acad. Sci. USA. 88, 2835–2839 (1991).

    Article  CAS  Google Scholar 

  6. Haisch, K. et al. Parasite Immunol. 23, 427–434 (2001).

    Article  CAS  Google Scholar 

  7. Min, B. et al. J. Exp. Med. 200, 507–517 (2004).

    Article  CAS  Google Scholar 

  8. Lim, L.H. et al. J. Immunol. 176, 5346–5353 (2006).

    Article  CAS  Google Scholar 

  9. Balic, A., Harcus, Y., Holland, M.J. & Maizels, R.M. Eur. J. Immunol. 34, 3047–3059 (2004).

    Article  CAS  Google Scholar 

  10. Ghaemmaghami, A.M., Gough, L., Sewell, H.F. & Shakib, F. Clin. Exp. Allergy 32, 1468–1475 (2002).

    Article  CAS  Google Scholar 

  11. Gauchat, J.F. et al. Nature 365, 340–343 (1993).

    Article  CAS  Google Scholar 

  12. Voehringer, D. et al. J. Exp. Med. 203, 1435–1446 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Booki Min is in the Department of Immunology at the Lerner Research Institute of the Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.,

    Booki Min

  2. William E. Paul is with the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. wpaul@niaid.nih.gov,

    William E Paul

Authors
  1. Booki Min
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. William E Paul
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Min, B., Paul, W. Basophils: in the spotlight at last. Nat Immunol 9, 223–225 (2008). https://doi.org/10.1038/ni0308-223

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0308-223

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing