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From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

Nature Immunology volume 13, pages 925–931 (2012)Cite this article

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Abstract

Feedback regulatory circuits provided by regulatory T cells (Treg cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory cytokines that have evolved to permit tolerance to components of self as well as the eradication of pathogens with minimal collateral damage to the host. Interleukin 2 (IL-2), IL-10 and transforming growth factor-β (TGF-β) are well characterized, whereas IL-27, IL-35 and IL-37 represent newcomers to the spectrum of anti-inflammatory cytokines. We also emphasize how information accumulated through in vitro as well as in vivo studies of genetically engineered mice can help in the understanding and treatment of human diseases.

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Figure 1: The dialog between Treg cells and DCs.
Figure 2: The dual roles of TGF-β in tolerance and immunity.
Figure 3: Members of the IL-12 family.

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Acknowledgements

We thank A. Howes for reading and proofing the manuscript. Supported by the Medical Research Council, UK (U117565642 to A.O.G.) and the US National Institutes of Health (ARO50770-02 and AIO82715 to V.P.).

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Authors and Affiliations

  1. Baylor Institute for Immunology Research, Dallas, Texas, USA

    Jacques Banchereau & Virginia Pascual

  2. Division of Immunoregulation, MRC National Institute for Medical Research, Mill Hill, London, UK

    Anne O'Garra

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  1. Jacques Banchereau
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  2. Virginia Pascual
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Correspondence to Jacques Banchereau.

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Banchereau, J., Pascual, V. & O'Garra, A. From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines. Nat Immunol 13, 925–931 (2012). https://doi.org/10.1038/ni.2406

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