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PKC-θ: hitting the bull's eye

Nature Immunology volume 12, pages 1031–1032 (2011)Cite this article

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How the kinase PKC-θ is targeted to the immunological synapse and is activated once there remains unclear. A targeting motif in PKC-θ and the previously unsuspected kinase GLK identified in two separate papers now explains this.

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Figure 1: Putative interconnections between selected TCR signaling pathways and CD28 costimulation.

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Authors and Affiliations

  1. Michael L. Dustin is with the Kimmel Center of Skirball Institute, New York University School of Medicine, New York, New York, USA.,

    Michael L Dustin

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  1. Michael L Dustin
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Correspondence to Michael L Dustin.

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The author declares no competing financial interests.

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Dustin, M. PKC-θ: hitting the bull's eye. Nat Immunol 12, 1031–1032 (2011). https://doi.org/10.1038/ni.2141

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