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A trithorax–like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

Nature Genetics volume 2, pages 113–118 (1992)Cite this article

An Erratum to this article was published on 01 August 1993

Abstract

Some acute lymphocytic leukaemias, particularly those in young children, are associated with a t(4;11)(q21;q23) reciprocal translocation. We have cloned the translocation breakpoint on chromosome 11q23 and isolated corresponding RNA transcripts from this region. The translocation occurs within a cluster of Alu repetitive elements located within an intron of a gene that gives rise to 11.5 (kb) transcript spanning the translocation breakpoint. The 11.5 kb transcript encodes a protein that is highly homologous to the Drosophila trithorax gene, a developmental regulator. An analysis of a series of leukaemic patients carrying t(4;11) and t(9;11) translocations indicate that the majority of breakpoints in infant leukaemias lie within a 5 kb region.

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Authors and Affiliations

  1. Molecular Genetics Laboratory, The Salk Institute for Biological Studies, La Jolla, California, 92037, USA

    Malek Djabali, Licia Selleri, Pauline Parry & Glen A. Evans

  2. ICRF Department of Medical Oncology, St Bartholomew's Hospital, London, EC1A 7BE, UK

    Mark Bower & Bryan D. Young

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Djabali, M., Selleri, L., Parry, P. et al. A trithorax–like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Genet 2, 113–118 (1992). https://doi.org/10.1038/ng1092-113

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