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Cancer, cadmium and genome integrity

Nature Genetics volume 34, pages 239–241 (2003)Cite this article

The direct inhibition of DNA mismatch repair by cadmium provides a molecular mechanism for cadmium toxicity with profound implications for human health, risk assessment and biological understanding of environmental mutagens. Alteration of key DNA damage response pathways may prove even more important than direct DNA damage by mutagens.

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Figure 1: A beautiful toxin.

Corel royalty-free art photo image 523028

Figure 2: Cadmium poisoning of MMR enzymes and resulting mutations.

Katie Ris

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Authors and Affiliations

  1. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, Rochester, 55905, Minnesota, USA

    Cynthia T McMurray

  2. Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, 92037, California, USA

    John A Tainer

  3. Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, 94720, California, USA

    John A Tainer

Authors
  1. Cynthia T McMurray
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  2. John A Tainer
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McMurray, C., Tainer, J. Cancer, cadmium and genome integrity. Nat Genet 34, 239–241 (2003). https://doi.org/10.1038/ng0703-239

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